CNIH4 - cornichon family AMPA receptor auxiliary protein 4 Gene

Also Known as CNIH2; CNIH-4; HSPC163

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29097

About CNIH4

Cytogenetic location: 1q42.11 Genomic coordinates (GRCh38): 1:224,356,803-224,379,452 (from NCBI)

This gene has 8 transcripts (splice variants), 212 orthologues and 4 paralogues. Ubiquitous expression in placenta (RPKM 7.6), colon (RPKM 7.3) and 25 other tissues.

Summary

Enables CCR5 Chemokine Receptor binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endoplasmic reticulum and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022]

CNIH4 Products (5)

mRNA Protein Name
NM_001277197.2 NP_001264126.1 protein cornichon homolog 4 isoform 2
NM_001277198.2 NP_001264127.1 protein cornichon homolog 4 isoform 3
NM_001277199.2 NP_001264128.1 protein cornichon homolog 4 isoform 4
NM_001277200.2 NP_001264129.1 protein cornichon homolog 4 isoform 5
NM_014184.4 NP_054903.1 protein cornichon homolog 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables CCR5 chemokine receptor binding IPI
IPI: Inferred from physical interaction
24405750 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24405750 GOA
Biological Process GO Annotation Evidence References Source
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
24405750 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
24405750 GOA
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: Inferred from direct assay
24405750 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNIH4 Protein Structure

Cornichon

Cornichon: Cornichon protein (3 - 131)

  • 0
  • 100
  • 139 a.a.
Protein Preferred Names Protein Names

protein cornichon homolog 4

  • cornichon homolog 4

Related Diseases

Diseases Alias
Mitochondrial Complex Ii Deficiency

  • Isolated Mitochondrial Respiratory Chain Complex Ii Deficiency

  • Isolated Succinate-Coenzyme Q Reductase Deficiency

  • Isolated Succinate-Coq Reductase Deficiency

  • Isolated Succinate-Ubiquinone Reductase Deficiency

  • Mitochondrial Respiratory Chain Complex Ii Deficiency

  • Complex 2 Mitochondrial Respiratory Chain Deficiency

  • Succinate Coq Reductase Deficiency

  • Succinate Dehydrogenase Deficiency

  • Isolated Succinate Dehydrogenase Deficiency

  • Succinate-Coenzyme Q Reductase Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02887 CNIH4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CNIH4 RGD RGD:1559740
Canis familiaris CNIH4 VGNC VGNC:39402
Felis catus CNIH4 VGNC VGNC:107861
Bos taurus CNIH4 VGNC VGNC:27504
Mus musculus CNIH4 MGD MGI:1925828
Macaca mulatta CNIH4 VGNC VGNC:71342
Others CNIH4 NCBI