Hnrnpa1 - heterogeneous nuclear ribonucleoprotein A1 Gene

Also Known as Hnrpa1; hnRNP A1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29578

Summary

Enables nucleic acid binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; cellular response to thapsigargin; and cellular response to tunicamycin. Located in cytosol and nucleoplasmic periphery of the nuclear pore complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 20; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3; and tropical spastic paraparesis. Orthologous to several human genes including HNRNPA1L2 (heterogeneous nuclear ribonucleoprotein A1 like 2). [provided by Alliance of Genome Resources, Apr 2022]

Hnrnpa1 Products (2)

mRNA Protein Name
NM_001399274.1 NP_001386203.1 heterogeneous nuclear ribonucleoprotein A1 isoform 1
NM_017248.3 NP_058944.2 heterogeneous nuclear ribonucleoprotein A1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA/DNA annealing activity IDA
IDA: Inferred from direct assay
1703006 RGD
enables RNA binding IDA
IDA: Inferred from direct assay
23159318 RGD
enables RNA strand annealing activity IDA
IDA: Inferred from direct assay
1703006 RGD
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
11723238 RGD
enables mRNA binding IDA
IDA: Inferred from direct assay
23106379 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16518874 RGD
enables sequence-specific mRNA binding IDA
IDA: Inferred from direct assay
11886857 RGD
enables single-stranded RNA binding IDA
IDA: Inferred from direct assay
7727389 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to epidermal growth factor stimulus IEP
IEP: Inferred from expression pattern
3062579 RGD
involved in cellular response to potassium ion IDA
IDA: Inferred from direct assay
17298175 RGD
involved in lung development IEP
IEP: Inferred from expression pattern
9457472 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
10978504 RGD
involved in positive regulation of action potential IMP
IMP: Inferred from mutant phenotype
15197740 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23106379 RGD
involved in response to endoplasmic reticulum stress IEP
IEP: Inferred from expression pattern
23106379 RGD
Cellular Component GO Annotation Evidence References Source
located in nucleoplasmic periphery of the nuclear pore complex IDA
IDA: Inferred from direct assay
10633080 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

heterogeneous nuclear ribonucleoprotein A1

  • HDP

  • helix-destabilizing protein

  • hnRNP core protein A1

  • single-strand RNA-binding protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06261 HNRNPA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19543 Hnrnpa1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26039 Hnrnpa1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hnrnpa1 NCBI NCBI:3178