Gja8 - gap junction protein, alpha 8 Gene

Rattus norvegicus

Also known as Cx50; Cxnl

Gene ID: 29601 | Gene type: protein coding

About Gja8

Summary

Enables identical protein binding activity. Contributes to gap junction channel activity. Involved in cell-cell signaling. Is integral component of membrane. Part of connexin complex. Used to study cataract; cataract 1 multiple types; and microphthalmia. Human ortholog(s) of this gene implicated in cataract and cataract 1 multiple types. Orthologous to human GJA8 (Gap Junction Protein alpha 8). [provided by Alliance of Genome Resources, Apr 2022]

Gja8 Products(1)

mRNA	Protein	Name
NM_153465.2	NP_703195.2	gap junction alpha-8 protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to gap junction channel activity	IDA IDA: Inferred from direct assay	16123426	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	16123426	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16123426	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell-cell signaling	IDA IDA: Inferred from direct assay	16123426	RGD
involved in regulation of catalase activity	IMP IMP: Inferred from mutant phenotype	27871290	RGD
involved in regulation of glutathione peroxidase activity	IMP IMP: Inferred from mutant phenotype	27871290	RGD
involved in regulation of granulocyte macrophage colony-stimulating factor production	IMP IMP: Inferred from mutant phenotype	27871290	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of connexin complex	IDA IDA: Inferred from direct assay	16123426	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

gap junction alpha-8 protein

connexin l	connexin-50
gap junction membrane channel protein alpha 8

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05445	GJA8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gja8	NCBI	NCBI:2703

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