HSD3B2 - Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 Gene

Rattus norvegicus

Also known as Hsd3b1; Hsd3b6; Hsd3b2l1

Gene ID: 29632 | Gene type: protein coding

About HSD3B2

Summary

Enables 3-beta-hydroxy-delta5-steroid dehydrogenase activity and steroid delta-isomerase activity. Involved in several processes, including Leydig cell differentiation; response to corticosterone; and steroid hormone biosynthetic process. Predicted to be located in endoplasmic reticulum; intercellular bridge; and nucleolus. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Biomarker of hyperprolactinemia and hypertension. Human ortholog(s) of this gene implicated in hypospadias. Orthologous to human HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Apr 2022]

HSD3B2 Products(1)

mRNA	Protein	Name
NM_017265.4	NP_058961.4	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	1985917	RGD
enables steroid delta-isomerase activity	IDA IDA: Inferred from direct assay	1985917	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in C21-steroid hormone biosynthetic process	IDA IDA: Inferred from direct assay	1985917	RGD
involved in Leydig cell differentiation	IEP IEP: Inferred from expression pattern	18502897	RGD
involved in androgen biosynthetic process	IDA IDA: Inferred from direct assay	1985917	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	21047951	RGD
involved in negative regulation of iron ion transport	IMP IMP: Inferred from mutant phenotype	16116051	RGD
involved in response to cadmium ion	IEP IEP: Inferred from expression pattern	18972398	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	8027581	RGD
involved in response to gonadotropin	IEP IEP: Inferred from expression pattern	16139340	RGD
involved in response to lead ion	IEP IEP: Inferred from expression pattern	18972398	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4

3 beta-hydroxysteroid dehydrogenase 6	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type IV
3-beta-HSD IV	Hydroxy-delta-5-steroid dehydrogenase 3 beta- and steroid delta-isomerase
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06402	HSD3B2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	HSD3B2	NCBI	NCBI:3284

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