Slc38a2 - solute carrier family 38, member 2 Gene

Rattus norvegicus

Also known as Ata2; Sat2; Atrc2; Snat2

Gene ID: 29642 | Gene type: protein coding

About Slc38a2

Summary

Enables L-glutamine transmembrane transporter activity and L-serine transmembrane transporter activity. Involved in several processes, including cellular response to mechanical stimulus; glycine betaine transport; and neutral amino acid transport. Located in several cellular components, including brush border; neuronal cell body; and sarcolemma. Biomarker of visual epilepsy. Orthologous to human SLC38A2 (solute carrier family 38 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc38a2 Products(1)

mRNA	Protein	Name
NM_181090.3	NP_851604.2	sodium-coupled neutral amino acid symporter 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-glutamine transmembrane transporter activity	IDA IDA: Inferred from direct assay	15218073	RGD
enables L-serine transmembrane transporter activity	IDA IDA: Inferred from direct assay	15218073	RGD
enables acidic amino acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	10811809	RGD
enables alanine:sodium symporter activity	IDA IDA: Inferred from direct assay	10811809	RGD
enables amino acid:sodium symporter activity	IDA IDA: Inferred from direct assay	12054432	RGD
enables neutral L-amino acid:sodium symporter activity	IDA IDA: Inferred from direct assay	10747860	RGD
enables proline:sodium symporter activity	IDA IDA: Inferred from direct assay	11716780	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-glutamine import across plasma membrane	IDA IDA: Inferred from direct assay	18832333	RGD
involved in L-proline import across plasma membrane	IDA IDA: Inferred from direct assay	11716780	RGD
involved in L-serine import across plasma membrane	IDA IDA: Inferred from direct assay	16629640	RGD
involved in L-serine transport	IDA IDA: Inferred from direct assay	15218073	RGD
involved in alanine transport	IDA IDA: Inferred from direct assay	10811809	RGD
involved in amino acid import	IDA IDA: Inferred from direct assay	11756489	RGD
involved in cellular response to amino acid starvation	IEP IEP: Inferred from expression pattern	11311116	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	15288886	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	21718781	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	19892400	RGD
involved in glutamine transport	IDA IDA: Inferred from direct assay	15218073	RGD
involved in glycine betaine transport	IDA IDA: Inferred from direct assay	24434061	RGD
involved in neutral amino acid transport	IDA IDA: Inferred from direct assay	10747860	RGD
involved in regulation of glutamate secretion, neurotransmission	IDA IDA: Inferred from direct assay	18832333	RGD
involved in response to muscle activity	IEP IEP: Inferred from expression pattern	24016666	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	15561425	RGD
located in brush border	IDA IDA: Inferred from direct assay	20338592	RGD
located in dendrite	IDA IDA: Inferred from direct assay	21718781	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15561425	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	11311116	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	11834730	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sodium-coupled neutral amino acid symporter 2

sodium-coupled neutral amino acid transporter 2

amino acid transporter A2	amino acid transporter cationic 2
amino acid transporter system A2	amino acid transporter, cationic 2 (low affinity)
system A amino acid transporter 2	system A transporter 1
system N amino acid transporter 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13220	SLC38A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22042	Slc38a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc38a2	NCBI	NCBI:54407

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