Kcnj10 - potassium inwardly-rectifying channel, subfamily J, member 10 Gene

Rattus norvegicus

Gene ID: 29718 | Gene type: protein coding

About Kcnj10

Summary

Enables identical protein binding activity and signaling receptor binding activity. Involved in several processes, including membrane hyperpolarization; potassium ion import across plasma membrane; and response to corticosteroid. Located in several cellular components, including astrocyte projection; basolateral plasma membrane; and microvillus. Used to study diabetic retinopathy. Biomarker of amyotrophic lateral sclerosis; brain disease (multiple); eye disease (multiple); and sensorineural hearing loss. Human ortholog(s) of this gene implicated in EAST syndrome and autosomal recessive nonsyndromic deafness 4. Orthologous to human KCNJ10 (potassium inwardly rectifying channel subfamily J member 10). [provided by Alliance of Genome Resources, Apr 2022]

Kcnj10 Products(1)

mRNA	Protein	Name
NM_031602.2	NP_113790.2	ATP-sensitive inward rectifier potassium channel 10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16206160	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10856114	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	21084311	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-glutamate import	IMP IMP: Inferred from mutant phenotype	17091490	RGD
involved in membrane hyperpolarization	IMP IMP: Inferred from mutant phenotype	17091490	RGD
involved in optic nerve development	IEP IEP: Inferred from expression pattern	15198689	RGD
involved in potassium ion import across plasma membrane	IMP IMP: Inferred from mutant phenotype	17091490	RGD
involved in response to blue light	IEP IEP: Inferred from expression pattern	18450590	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	20466875	RGD
involved in response to mineralocorticoid	IEP IEP: Inferred from expression pattern	20466875	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	18395087	RGD
located in astrocyte projection	IDA IDA: Inferred from direct assay	20833221	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	18303016	RGD
located in microvillus	IDA IDA: Inferred from direct assay	20466875	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ATP-sensitive inward rectifier potassium channel 10

ATP-sensitive inward rectifier potassium channel KAB-2	BIR10
BIRK1	brain-specific inwardly rectifying K(+) channel 1
inward rectifier K(+) channel Kir4.1	kir4.1
potassium channel, inwardly rectifying subfamily J member 10	potassium voltage-gated ch

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07137	KCNJ10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnj10	NCBI	NCBI:3766

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