Kcnj10 - potassium inwardly-rectifying channel, subfamily J, member 10 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29718

Summary

Enables identical protein binding activity and signaling receptor binding activity. Involved in several processes, including membrane hyperpolarization; potassium ion import across plasma membrane; and response to corticosteroid. Located in several cellular components, including astrocyte projection; basolateral plasma membrane; and microvillus. Used to study diabetic retinopathy. Biomarker of amyotrophic lateral sclerosis; brain disease (multiple); eye disease (multiple); and sensorineural hearing loss. Human ortholog(s) of this gene implicated in EAST syndrome and autosomal recessive nonsyndromic deafness 4. Orthologous to human KCNJ10 (potassium inwardly rectifying channel subfamily J member 10). [provided by Alliance of Genome Resources, Apr 2022]

Kcnj10 Products (1)

mRNA Protein Name
NM_031602.2 NP_113790.2 ATP-sensitive inward rectifier potassium channel 10

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16206160 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10856114 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
21084311 RGD
Biological Process GO Annotation Evidence References Source
involved in L-glutamate import IMP
IMP: Inferred from mutant phenotype
17091490 RGD
involved in membrane hyperpolarization IMP
IMP: Inferred from mutant phenotype
17091490 RGD
involved in optic nerve development IEP
IEP: Inferred from expression pattern
15198689 RGD
involved in potassium ion import across plasma membrane IMP
IMP: Inferred from mutant phenotype
17091490 RGD
involved in response to blue light IEP
IEP: Inferred from expression pattern
18450590 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
20466875 RGD
involved in response to mineralocorticoid IEP
IEP: Inferred from expression pattern
20466875 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
18395087 RGD
located in astrocyte projection IDA
IDA: Inferred from direct assay
20833221 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
18303016 RGD
located in microvillus IDA
IDA: Inferred from direct assay
20466875 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-sensitive inward rectifier potassium channel 10

  • ATP-sensitive inward rectifier potassium channel KAB-2

  • BIR10

  • BIRK1

  • brain-specific inwardly rectifying K(+) channel 1

  • inward rectifier K(+) channel Kir4.1

  • kir4.1

  • potassium channel, inwardly rectifying subfamily J member 10

  • potassium voltage-gated ch

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07137 KCNJ10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnj10 NCBI NCBI:3766