Slc19a1 - solute carrier family 19 member 1 Gene

Rattus norvegicus

Also known as MTX1; MTX-1

Gene ID: 29723 | Gene type: protein coding

About Slc19a1

Summary

Enables folate:anion antiporter activity; folic acid binding activity; and methotrexate transmembrane transporter activity. Involved in female pregnancy; folic acid transport; and methotrexate transport. Located in apical plasma membrane; basolateral plasma membrane; and brush border membrane. Biomarker of chronic kidney disease. Human ortholog(s) of this gene implicated in cleft lip; dextro-looped transposition of the great arteries; hematologic cancer; and malaria. Orthologous to human SLC19A1 (solute carrier family 19 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc19a1 Products(2)

mRNA	Protein	Name
NM_001035232.1	NP_001030309.1	reduced folate transporter
NM_017299.2	NP_058995.2	reduced folate transporter

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables folate:monoatomic anion antiporter activity	IDA IDA: Inferred from direct assay	11600421	RGD
enables folic acid binding	IDA IDA: Inferred from direct assay	11600421	RGD
enables methotrexate transmembrane transporter activity	IDA IDA: Inferred from direct assay	10827155	RGD
enables organic anion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	18762716	RGD
enables xenobiotic transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	21737571	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in female pregnancy	IEP IEP: Inferred from expression pattern	18776693	RGD
involved in methotrexate transport	IDA IDA: Inferred from direct assay	10827155	RGD
involved in organic anion transport	IMP IMP: Inferred from mutant phenotype	18762716	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	20451541	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	20451541	RGD
involved in xenobiotic transmembrane transport	IMP IMP: Inferred from mutant phenotype	21737571	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	21556118	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	15846510	RGD
located in brush border membrane	IDA IDA: Inferred from direct assay	23287122	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

reduced folate transporter

RFC-1	RFC1
folate transporter 1	methotrexate carrier 1
methotrexate carrier 2	methotrexate carrier 5
methotrexate carrier 6	plasma membrane folate antiporter SLC19A1
reduced folate carrier 1	solute carrier family 19 (folate transporter), member 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13047	SLC19A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc19a1	NCBI	NCBI:6573

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