Slc19a1 - solute carrier family 19 member 1 Gene

Also Known as MTX1; MTX-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29723

Summary

Enables folate:anion antiporter activity; folic acid binding activity; and methotrexate transmembrane transporter activity. Involved in female pregnancy; folic acid transport; and methotrexate transport. Located in apical plasma membrane; basolateral plasma membrane; and brush border membrane. Biomarker of chronic kidney disease. Human ortholog(s) of this gene implicated in cleft lip; dextro-looped transposition of the great arteries; hematologic cancer; and malaria. Orthologous to human SLC19A1 (solute carrier family 19 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc19a1 Products (2)

mRNA Protein Name
NM_001035232.1 NP_001030309.1 reduced folate transporter
NM_017299.2 NP_058995.2 reduced folate transporter

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables folate:monoatomic anion antiporter activity IDA
IDA: Inferred from direct assay
11600421 RGD
enables folic acid binding IDA
IDA: Inferred from direct assay
11600421 RGD
enables methotrexate transmembrane transporter activity IDA
IDA: Inferred from direct assay
10827155 RGD
enables organic anion transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
18762716 RGD
enables xenobiotic transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
21737571 RGD
Biological Process GO Annotation Evidence References Source
involved in female pregnancy IEP
IEP: Inferred from expression pattern
18776693 RGD
involved in methotrexate transport IDA
IDA: Inferred from direct assay
10827155 RGD
involved in organic anion transport IMP
IMP: Inferred from mutant phenotype
18762716 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
20451541 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
20451541 RGD
involved in xenobiotic transmembrane transport IMP
IMP: Inferred from mutant phenotype
21737571 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
21556118 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
15846510 RGD
located in brush border membrane IDA
IDA: Inferred from direct assay
23287122 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

reduced folate transporter

  • RFC-1

  • RFC1

  • folate transporter 1

  • methotrexate carrier 1

  • methotrexate carrier 2

  • methotrexate carrier 5

  • methotrexate carrier 6

  • plasma membrane folate antiporter SLC19A1

  • reduced folate carrier 1

  • solute carrier family 19 (folate transporter), member 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13047 SLC19A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc19a1 NCBI NCBI:6573