GULOP - gulonolactone (L-) oxidase, pseudogene Gene

Homo sapiens

Also known as GULO; SCURVY

Gene ID: 2989 | Gene type: pseudo

About GULOP

Cytogenetic location: 8p21.1 Genomic coordinates (GRCh38): 8:27,500,001-29,000,000

Summary

This gene is nonfunctional in humans and Other primates. In most mammalian species the corresponding gene encodes L-gulono-gamma-lactone oxidase which catalyzes the last step of ascorbic acid biosynthesis. The human gene is a remnant that lacks five of twelve exons found in functional rodent genes. The loss of enzyme activity results in hypoascorbemia or the inability to synthesize vitamin C. [provided by RefSeq, Nov 2010]

Related Diseases

Diseases

Alias

Hypoascorbemia

Scurvy	Ascorbic Acid Deficiency
Vitamin C Deficiency	Vitamin C, Inability To Synthesize
Deficiency Of Vitamin C	Scorbutus
Vitamin C

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-165104	β-L-Gulopyranosyl-caldarchaetidyl-glycerol	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GULOP	MGD	MGI:1353434

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