Brf1 - BRF1, RNA polymerase III transcription initiation factor subunit Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 299347

Summary

Predicted to enable RNA polymerase III general transcription initiation factor activity and RNA polymerase III type 3 promoter sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase III. Predicted to be part of transcription factor TFIIIB complex and transcription preinitiation complex. Predicted to be active in nucleus. Used to study fibroma. Human ortholog(s) of this gene implicated in cerebellofaciodental syndrome. Orthologous to human BRF1 (BRF1 RNA polymerase III transcription initiation factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Brf1 Products (1)

mRNA Protein Name
NM_001399505.1 NP_001386434.1 transcription factor IIIB 90 kDa subunit

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase III IMP
IMP: Inferred from mutant phenotype
18456653 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor IIIB 90 kDa subunit

  • BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB

  • BRF1, RNA polymerase III transcription initiation factor 90 subunit

Orthologs Information

Species Symbol Source ID
Homo sapiens Brf1 NCBI NCBI:2972