SORL1 - Sorl1 sortilin related receptor 1 Gene

Also Known as Lr11; SorLA; RGD619914

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 300652

Summary

Predicted to enable several functions, including low-density lipoprotein particle binding activity; peptide binding activity; and small GTPase binding activity. Involved in cell migration and cell population proliferation. Located in multivesicular body and neuronal cell body. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SORL1 (sortilin related receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

SORL1 Products (1)

mRNA	Protein	Name
NM_053519.1	NP_445971.1	sortilin-related receptor precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	11956127	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in multivesicular body	IDA IDA: Inferred from direct assay	16452683	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	10867025	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
sortilin-related receptor	LDLR relative with 11 ligand-binding repeats low-density lipoprotein receptor relative with 11 ligand-binding repeats sortilin-related receptor, LDLR class A repeats-containing sortilin-related receptor-like sorting protein-related receptor containing

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13574	SORL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21763	Sorl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	SORL1	NCBI	NCBI:6653