H3-3B - H3.3 histone B Gene

Homo sapiens

Also known as H3-3A; H3.3B; H3F3B; BRYLIB2

Gene ID: 3021 | Gene type: protein coding

About H3-3B

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,776,434-75,779,779 (from NCBI)

This gene has 13 transcripts (splice variants), 111 orthologues, 20 paralogues and is associated with 70 phenotypes. Broad expression in bone marrow (RPKM 868.3), ovary (RPKM 358.6) and 24 other tissues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. Pseudogenes of this gene have been identified on the X chromosome, and on chromosomes 5, 13 and 17. [provided by RefSeq, Oct 2015]

H3-3B Products(1)

mRNA	Protein	Name
NM_005324.5	NP_005315.1	histone H3.3

H3-3B Protein Structure

Histone

0
100
136 a.a.

Protein Preferred Names

Protein Names

histone H3.3

H3 histone family member 3B

Related Diseases

Diseases

Alias

Bryant-Li-Bhoj Neurodevelopmental Syndrome 2

BRYLIB2

Chondroblastoma

Chondroblastoma Of Bone

Clear Cell Chondrosarcoma

Chondrosarcoma, Clear Cell

Brain Stem Cancer

Brain Stem Neoplasms	Malignant Neoplasm Of Brain Stem
Malignant Neoplasm Of Brainstem	Neoplasm Of Adult Brain Stem
Neoplasm Of Brain Stem	Primary Brain Stem Neoplasm
Primary Brain Stem Tumor	Brain Stem Neoplasm
Brain Stem--Cancer	Brain Stem Neoplasms, Primary

Bone Giant Cell Sarcoma

Giant Cell Sarcoma Of The Bone

Giant Cell Tumor Of Bone, Malignant

Malignant Giant Cell Tumor

Malignant Tumor, Giant Cell Type

Malignant Giant Cell Neoplasm

Adult Brain Stem Glioma

Adult Brainstem Neuroglial Tumor

Childhood Brain Stem Glioma

Pediatric Glioma Of The Brainstem

Spinal Cord Astrocytoma

Astrocytoma Of Spinal Cord

Spinal Astrocytoma

Anaplastic Pleomorphic Xanthoastrocytoma

Histone Mutated Tumor

Histone Mutated Tumour

Spinal Cord Glioma

Glial Tumor Of Spinal Cord	Glial Neoplasm Spinal Cord
Glioma Of Spinal Cord

Telangiectatic Osteogenic Sarcoma

Telangiectatic Osteosarcoma

Bone Benign Neoplasm

Diffuse Midline Glioma, H3 K27m-Mutant

Diffuse Intrinsic Pontine Glioma	Dipg
Infiltrative Brainstem Glioma

Childhood Oligodendroglioma

Pediatric Oligodendroglioma

Oligodendroglioma, Childhood

Connective Tissue Benign Neoplasm

Soft Tissue Neoplasms	Mesenchymal Tissue Neoplasm
Neoplasm Of Soft Tissue	Neoplasm Of Soft Tissues
Soft Tissue Benign Neoplasm	Tumor Of The Soft Tissue
Soft Tissue Neoplasm

Pleomorphic Xanthoastrocytoma

Pxa	Pleomorphic Xantho-Astrocytoma

Posterior Fossa Ependymoma

Idh-Wildtype Glioblastoma

Astrocytoma, Idh-Mutant, Grade 4

Idh-Mutant Glioblastoma

Adult Astrocytic Tumour

Adult Astrocytoma

Adult Astrocytic Tumors

Brain Stem Glioma

Brainstem Glioma	Brainstem Neuroglial Tumor
Glioma Of Brainstem

Bone Giant Cell Tumor

Giant Cell Tumor Of Bone	Osteoclastoma
Gct Of Bone	Bone Giant Cell Tumour
Giant Cell Myeloma	Giant Cell Neoplasm Of Bone
Giant Cell Tumour Of Bone

Diffuse Astrocytoma

Diffuse Astrocytoma, Low Grade	Who Grade Ii Astrocytoma
Fibrillary Astrocytoma	Gemistocytic Astrocytoma
Low-Grade Diffuse Astrocytoma	Protoplasmic Astrocytoma

Adult Oligodendroglioma

Adult Brain Oligodendroglioma	Grade Ii Adult Oligodendroglial Tumor
Oligodendroglioma, Adult

Idh-Wildtype Anaplastic Astrocytoma

Gliomatosis Cerebri

Astrocytosis Cerebri

Neoplasms, Neuroepithelial

Spinal Cancer

Spinal Cord Neoplasm	Spinal Cord Neoplasms
Spinal Neoplasms	Intraspinal Tumor
Malignant Tumor Of The Spinal Cord	Spinal Cord Cancer
Spinal Neoplasm	Tumor Of The Spinal Cord
Tumors Spinal Cord	Intraspinal Neoplasm
Spinal Cord--Cancer

Supratentorial Ependymoma

High Grade Ependymoma

Ependymal Neoplasm	Ependymal Tumors
Malignant Ependymoma	Ependymal Tumor
Anaplastic Ependymoma	Experimental Organism Malignant Ependymoma
Ependymoma Of Brain

Ossifying Fibroma

Peripheral Ossifying Fibroma	Fibro-Osteoma
Fibroma Ossifying	Fibroma, Ossifying

Periosteal Osteogenic Sarcoma

Periosteal Osteosarcoma

Parosteal Osteosarcoma

Benign Giant Cell Tumor

Giant Cell Tumors

Hutchinson-Gilford Progeria Syndrome

Progeria	HGPS
Hutchinson-Gilford Syndrome	Hutchinson-Gilford Progeria
Hutchinson Gilford Syndrome	Hutchinson Gilford Progeria Syndrome
Hutchinson-Gilford Disease	Progeria Of Childhood
Hutchinson-Gilford-Progeria Syndrome

Low Grade Glioma

Benign Glioma

Diffuse Large B-Cell Lymphoma

Dlbcl	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Large B-Cell Diffuse Lymphoma	Lymphoma, Large B-Cell, Diffuse
Dlbcl - [Diffuse Large B-Cell Lymphoma]	Diffuse Large Beta Cell Lymphoma

Lung Combined Type Small Cell Carcinoma

Combined Small Cell Carcinoma Of The Lung

Combined Type Small Cell Carcinoma Of Lung

Dysembryoplastic Neuroepithelial Tumor

Dysembryoplastic Neuroepithelial Tumour	Dysembryoplastic Neuroepithelial Neoplasm
Dnet

Chondroblastic Osteosarcoma

Chondrosarcomatous Osteogenic Sarcoma

Brain Stem Astrocytic Neoplasm

Brainstem Astrocytoma

Astrocytoma Of Brain Stem

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Cerebral Ventricle Cancer

Cerebral Ventricle Neoplasms	Cerebral Ventricle Neoplasm
Intraventricular Tumor Of Brain

Central Nervous System Benign Neoplasm

Benign Neoplasm Of The Central Nervous System

Oculoectodermal Syndrome

Aplasia Cutis Congenita With Epibulbar Dermoids	Toriello-Lacassie-Droste Syndrome
Oculoectodermal Syndrome, Somatic	OES
Aplasia Cutis Congenita-Epibulbar Dermoids Syndrome	Oculo-Ectodermal Syndrome
Toriello Lacassie Droste Syndrome

Juvenile Pilocytic Astrocytoma

Pilomyxoid Astrocytoma

Supratentorial Cancer

Supratentorial Neoplasms	Brain Neoplasm, Supratentorial
Malignant Supratentorial Tumor	Cancer, Supratentorial

Cerebrum Cancer

Cerebral Cancer	Neoplasm Of Cerebrum
Tumor Of Cerebrum	Malignant Neoplasm Of Cerebrum

Fibrillary Astrocytoma

Fibrillary Astrocytic Tumors	Diffuse Astrocytoma
Gemistocytic Astrocytoma	Protoplasmic Astrocytoma

Childhood Astrocytic Tumor

Juvenile Astrocytoma

Pediatric Astrocytoma

Peripheral Osteosarcoma

Surface Osteosarcoma

Bone Surface Osteosarcoma

Spinal Cord Disease

Spinal Cord Diseases	Myelopathy
Bone Marrow Diseases

Obstructive Hydrocephalus

Anaplastic Ependymoma

Ependymoma, Anaplastic

Undifferentiated Ependymoma

Pilocytic Astrocytoma

Juvenile Pilocytic Astrocytoma	Grade I Astrocytic Tumor
Piloid Astrocytoma

Atypical Teratoid Rhabdoid Tumor

Rhabdoid Tumor Predisposition Syndrome	Rtps
Atypical Teratoid/Rhabdoid Tumor	Rhabdoid Predisposition Syndrome
Familial Posterior Fossa Brain Tumor Of Infancy	Familial Rhabdoid Tumor
At/Rt	Atypical Teratoid Rhabdoid Tumour
Atypical Teratoid/Rhabdoid Tumour	Rhabdoid Tumor Of The Cns
Rhabdoid Tumour Of The Cns	Familial Posterior Fossa Brain Tumor Syndrome
Hereditary Swi/Snf Deficiency Syndrome	Atrt

Anaplastic Oligodendroglioma

Alpha Thalassemia-X-Linked Intellectual Disability Syndrome

Atr-X Syndrome	Atr, Nondeletion Type
Alpha-Thalassemia X-Linked Intellectual Disability Syndrome	Atrx Syndrome
Alpha-Thalassemia/Mental Retardation Syndrome Nondeletion Type	Alpha Thalassemia Intellectual Disability Syndrome, Nondeletion Type, X-Linked
X-Linked Alpha-Thalassemia/Intellectual Disability Syndrome	Xlmr Hypotonic Face Syndrome
Alpha Thalassemia X-Linked Intellectual Disability Syndrome	Alpha Thalassemia X-Linked Mental Retardation Syndrome
Alpha Thalassemia/Mental Retardation, X-Linked	Alpha-Thalassemia X-Linked Mental Retardation Syndrome
Alpha-Thalassemia/Mental Retardation Syndrome, Nondeletion Type	X-Linked Alpha-Thalassemia/Mental Retardation Syndrome
Xlmr-Hypotonic Face Syndrome	Alpha-Thalassemia-X-Linked Intellectual Disability Syndrome
Alpha-Thalassemia/Mental Retardation Syndrome, Nondeletion Type, X-Linked

Infratentorial Cancer

Infratentorial Neoplasms	Brain Neoplasm, Infratentorial
Malignant Infratentorial Tumors

Multiple Enchondromatosis, Maffucci Type

Maffucci Syndrome	Chondrodysplasia With Hemangioma
Chondroplasia Angiomatosis	Enchondromatosis With Hemangiomata
Hemangiomatosis Chondrodystrophica	Kast Syndrome
Multiple Angiomas And Endochondromas	Dyschondrodysplasia With Hemangiomas
Enchondromatosis Type Ii	Enchondromatosis With Multiple Cavernous Hemangiomas
Dyschondroplasia And Cavernous Hemangioma	Hemangiomata With Dyschondroplasia

Anaplastic Astrocytoma

Grade Iii Astrocytoma	Astrocytoma, Anaplastic
Grade Iii Astrocytic Tumor

Alpha-Thalassemia

Alpha Thalassemia	Alpha Thalassaemia
Alpha Plus Thalassemia	Thalassemia, Alpha-
Thalassemias, Alpha-	A-Thalassemia
Α-Thalassemia	A-THAL
Thalassemia	Alpha Thalassaemia Syndrome

Brain Glioma

Lower Grade Glioma	Intracranial Glioma
Glioma Nos

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Intracranial Cavernous Angioma

Intracranial Cavernoma

Intracranial Cavernous Hemangioma

Intracranial Structure Hemangioma

Angioma Of Intracranial Structure	Hemangioma Of Intracranial Structure
Hemangioma Of Intracranial Structures

Colon Leiomyoma

Colonic Leiomyoma

Giant Cell Glioblastoma

Monstrocellular Sarcoma

Gliosarcoma

Glioblastoma With Sarcomatous Component

Sarcomatous Glioblastoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05962	H3-3B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	H3-3B	RGD	RGD:621095
Mus musculus	H3-3B	MGD	MGI:1101768