H3-3B - H3.3 histone B Gene

Also Known as H3-3A; H3.3B; H3F3B; BRYLIB2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3021

About H3-3B

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,776,434-75,779,779 (from NCBI)

This gene has 13 transcripts (splice variants), 111 orthologues, 20 paralogues and is associated with 70 phenotypes. Broad expression in bone marrow (RPKM 868.3), ovary (RPKM 358.6) and 24 other tissues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. Pseudogenes of this gene have been identified on the X chromosome, and on chromosomes 5, 13 and 17. [provided by RefSeq, Oct 2015]

H3-3B Products (1)

mRNA	Protein	Name
NM_005324.5	NP_005315.1	histone H3.3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19633671	GOA
enables RNA polymerase II core promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19633671	GOA
enables nucleosomal DNA binding	IDA IDA: Inferred from direct assay	19633671	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19494831	GOA
enables structural constituent of chromatin	IDA IDA: Inferred from direct assay	14718166	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in nucleosome assembly	IDA IDA: Inferred from direct assay	21636898	GOA
involved in nucleosome assembly	IMP IMP: Inferred from mutant phenotype	25615412	GOA
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	21274551	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	20110566	GOA
part of nucleosome	IDA IDA: Inferred from direct assay	14718166	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21636898	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	34876591	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	14718166	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H3-3B Protein Structure

Histone

0
100
136 a.a.

Protein Preferred Names	Protein Names
histone H3.3	H3 histone family member 3B

H3-3B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86113	Histone H3 (Di Methyl Lys4) Antibody (YA5805)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Bryant-Li-Bhoj Neurodevelopmental Syndrome 2	BRYLIB2
Chondroblastoma	Chondroblastoma Of Bone
Clear Cell Chondrosarcoma	Chondrosarcoma, Clear Cell
Brain Stem Cancer	Brain Stem Neoplasms Malignant Neoplasm Of Brain Stem Malignant Neoplasm Of Brainstem Neoplasm Of Adult Brain Stem Neoplasm Of Brain Stem Primary Brain Stem Neoplasm Primary Brain Stem Tumor Brain Stem Neoplasm Brain Stem--Cancer Brain Stem Neoplasms, Primary
Bone Giant Cell Sarcoma	Giant Cell Sarcoma Of The Bone Giant Cell Tumor Of Bone, Malignant
Malignant Giant Cell Tumor	Malignant Tumor, Giant Cell Type Malignant Giant Cell Neoplasm
Adult Brain Stem Glioma	Adult Brainstem Neuroglial Tumor
Childhood Brain Stem Glioma	Pediatric Glioma Of The Brainstem
Spinal Cord Astrocytoma	Astrocytoma Of Spinal Cord Spinal Astrocytoma
Anaplastic Pleomorphic Xanthoastrocytoma
Histone Mutated Tumor	Histone Mutated Tumour
Spinal Cord Glioma	Glial Tumor Of Spinal Cord Glial Neoplasm Spinal Cord Glioma Of Spinal Cord
Telangiectatic Osteogenic Sarcoma	Telangiectatic Osteosarcoma
Bone Benign Neoplasm
Diffuse Midline Glioma, H3 K27m-Mutant	Diffuse Intrinsic Pontine Glioma Dipg Infiltrative Brainstem Glioma
Childhood Oligodendroglioma	Pediatric Oligodendroglioma Oligodendroglioma, Childhood
Connective Tissue Benign Neoplasm	Soft Tissue Neoplasms Mesenchymal Tissue Neoplasm Neoplasm Of Soft Tissue Neoplasm Of Soft Tissues Soft Tissue Benign Neoplasm Tumor Of The Soft Tissue Soft Tissue Neoplasm
Pleomorphic Xanthoastrocytoma	Pxa Pleomorphic Xantho-Astrocytoma
Posterior Fossa Ependymoma
Idh-Wildtype Glioblastoma
Astrocytoma, Idh-Mutant, Grade 4	Idh-Mutant Glioblastoma
Adult Astrocytic Tumour	Adult Astrocytoma Adult Astrocytic Tumors
Brain Stem Glioma	Brainstem Glioma Brainstem Neuroglial Tumor Glioma Of Brainstem
Bone Giant Cell Tumor	Giant Cell Tumor Of Bone Osteoclastoma Gct Of Bone Bone Giant Cell Tumour Giant Cell Myeloma Giant Cell Neoplasm Of Bone Giant Cell Tumour Of Bone
Diffuse Astrocytoma	Diffuse Astrocytoma, Low Grade Who Grade Ii Astrocytoma Fibrillary Astrocytoma Gemistocytic Astrocytoma Low-Grade Diffuse Astrocytoma Protoplasmic Astrocytoma
Adult Oligodendroglioma	Adult Brain Oligodendroglioma Grade Ii Adult Oligodendroglial Tumor Oligodendroglioma, Adult
Idh-Wildtype Anaplastic Astrocytoma
Gliomatosis Cerebri	Astrocytosis Cerebri Neoplasms, Neuroepithelial
Spinal Cancer	Spinal Cord Neoplasm Spinal Cord Neoplasms Spinal Neoplasms Intraspinal Tumor Malignant Tumor Of The Spinal Cord Spinal Cord Cancer Spinal Neoplasm Tumor Of The Spinal Cord Tumors Spinal Cord Intraspinal Neoplasm Spinal Cord--Cancer
Supratentorial Ependymoma
High Grade Ependymoma	Ependymal Neoplasm Ependymal Tumors Malignant Ependymoma Ependymal Tumor Anaplastic Ependymoma Experimental Organism Malignant Ependymoma Ependymoma Of Brain
Ossifying Fibroma	Peripheral Ossifying Fibroma Fibro-Osteoma Fibroma Ossifying Fibroma, Ossifying
Periosteal Osteogenic Sarcoma	Periosteal Osteosarcoma Parosteal Osteosarcoma
Benign Giant Cell Tumor	Giant Cell Tumors
Hutchinson-Gilford Progeria Syndrome	Progeria HGPS Hutchinson-Gilford Syndrome Hutchinson-Gilford Progeria Hutchinson Gilford Syndrome Hutchinson Gilford Progeria Syndrome Hutchinson-Gilford Disease Progeria Of Childhood Hutchinson-Gilford-Progeria Syndrome
Low Grade Glioma	Benign Glioma
Diffuse Large B-Cell Lymphoma	Dlbcl Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Large B-Cell Diffuse Lymphoma Lymphoma, Large B-Cell, Diffuse Dlbcl - [Diffuse Large B-Cell Lymphoma] Diffuse Large Beta Cell Lymphoma
Lung Combined Type Small Cell Carcinoma	Combined Small Cell Carcinoma Of The Lung Combined Type Small Cell Carcinoma Of Lung
Dysembryoplastic Neuroepithelial Tumor	Dysembryoplastic Neuroepithelial Tumour Dysembryoplastic Neuroepithelial Neoplasm Dnet
Chondroblastic Osteosarcoma	Chondrosarcomatous Osteogenic Sarcoma
Brain Stem Astrocytic Neoplasm	Brainstem Astrocytoma Astrocytoma Of Brain Stem
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Cerebral Ventricle Cancer	Cerebral Ventricle Neoplasms Cerebral Ventricle Neoplasm Intraventricular Tumor Of Brain
Central Nervous System Benign Neoplasm	Benign Neoplasm Of The Central Nervous System
Oculoectodermal Syndrome	Aplasia Cutis Congenita With Epibulbar Dermoids Toriello-Lacassie-Droste Syndrome Oculoectodermal Syndrome, Somatic OES Aplasia Cutis Congenita-Epibulbar Dermoids Syndrome Oculo-Ectodermal Syndrome Toriello Lacassie Droste Syndrome
Juvenile Pilocytic Astrocytoma
Pilomyxoid Astrocytoma
Supratentorial Cancer	Supratentorial Neoplasms Brain Neoplasm, Supratentorial Malignant Supratentorial Tumor Cancer, Supratentorial
Cerebrum Cancer	Cerebral Cancer Neoplasm Of Cerebrum Tumor Of Cerebrum Malignant Neoplasm Of Cerebrum
Fibrillary Astrocytoma	Fibrillary Astrocytic Tumors Diffuse Astrocytoma Gemistocytic Astrocytoma Protoplasmic Astrocytoma
Childhood Astrocytic Tumor	Juvenile Astrocytoma Pediatric Astrocytoma
Peripheral Osteosarcoma	Surface Osteosarcoma Bone Surface Osteosarcoma
Spinal Cord Disease	Spinal Cord Diseases Myelopathy Bone Marrow Diseases
Obstructive Hydrocephalus
Anaplastic Ependymoma	Ependymoma, Anaplastic Undifferentiated Ependymoma
Pilocytic Astrocytoma	Juvenile Pilocytic Astrocytoma Grade I Astrocytic Tumor Piloid Astrocytoma
Atypical Teratoid Rhabdoid Tumor	Rhabdoid Tumor Predisposition Syndrome Rtps Atypical Teratoid/Rhabdoid Tumor Rhabdoid Predisposition Syndrome Familial Posterior Fossa Brain Tumor Of Infancy Familial Rhabdoid Tumor At/Rt Atypical Teratoid Rhabdoid Tumour Atypical Teratoid/Rhabdoid Tumour Rhabdoid Tumor Of The Cns Rhabdoid Tumour Of The Cns Familial Posterior Fossa Brain Tumor Syndrome Hereditary Swi/Snf Deficiency Syndrome Atrt
Anaplastic Oligodendroglioma
Alpha Thalassemia-X-Linked Intellectual Disability Syndrome	Atr-X Syndrome Atr, Nondeletion Type Alpha-Thalassemia X-Linked Intellectual Disability Syndrome Atrx Syndrome Alpha-Thalassemia/Mental Retardation Syndrome Nondeletion Type Alpha Thalassemia Intellectual Disability Syndrome, Nondeletion Type, X-Linked X-Linked Alpha-Thalassemia/Intellectual Disability Syndrome Xlmr Hypotonic Face Syndrome Alpha Thalassemia X-Linked Intellectual Disability Syndrome Alpha Thalassemia X-Linked Mental Retardation Syndrome Alpha Thalassemia/Mental Retardation, X-Linked Alpha-Thalassemia X-Linked Mental Retardation Syndrome Alpha-Thalassemia/Mental Retardation Syndrome, Nondeletion Type X-Linked Alpha-Thalassemia/Mental Retardation Syndrome Xlmr-Hypotonic Face Syndrome Alpha-Thalassemia-X-Linked Intellectual Disability Syndrome Alpha-Thalassemia/Mental Retardation Syndrome, Nondeletion Type, X-Linked
Infratentorial Cancer	Infratentorial Neoplasms Brain Neoplasm, Infratentorial Malignant Infratentorial Tumors
Multiple Enchondromatosis, Maffucci Type	Maffucci Syndrome Chondrodysplasia With Hemangioma Chondroplasia Angiomatosis Enchondromatosis With Hemangiomata Hemangiomatosis Chondrodystrophica Kast Syndrome Multiple Angiomas And Endochondromas Dyschondrodysplasia With Hemangiomas Enchondromatosis Type Ii Enchondromatosis With Multiple Cavernous Hemangiomas Dyschondroplasia And Cavernous Hemangioma Hemangiomata With Dyschondroplasia
Anaplastic Astrocytoma	Grade Iii Astrocytoma Astrocytoma, Anaplastic Grade Iii Astrocytic Tumor
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome
Brain Glioma	Lower Grade Glioma Intracranial Glioma Glioma Nos
Bone Osteosarcoma	Osteosarcoma Of Bone Primary Osteosarcoma Of Bone
Intracranial Cavernous Angioma	Intracranial Cavernoma Intracranial Cavernous Hemangioma
Intracranial Structure Hemangioma	Angioma Of Intracranial Structure Hemangioma Of Intracranial Structure Hemangioma Of Intracranial Structures
Colon Leiomyoma	Colonic Leiomyoma
Giant Cell Glioblastoma	Monstrocellular Sarcoma
Gliosarcoma	Glioblastoma With Sarcomatous Component Sarcomatous Glioblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05962	H3-3B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05961	H3-3A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	H3-3B	RGD	RGD:621095
Mus musculus	H3-3B	MGD	MGI:1101768
Others	H3-3B	NCBI