Mapk8ip3 - mitogen-activated protein kinase 8 interacting protein 3 Gene

Rattus norvegicus

Also known as JIP3; JIP-3; JSAP1

Gene ID: 302983 | Gene type: protein coding

About Mapk8ip3

Summary

Enables mitogen-activated protein kinase kinase binding activity. Involved in several processes, including anterograde axonal protein transport; axon regeneration; and positive regulation of JNK cascade. Located in several cellular components, including cell body; dendrite; and perinuclear region of cytoplasm. Orthologous to human MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Mapk8ip3 Products(1)

mRNA	Protein	Name
NM_001100673.2	NP_001094143.2	C-Jun-amino-terminal kinase-interacting protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mitogen-activated protein kinase kinase binding	IPI IPI: Inferred from physical interaction	16805806	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	21076496	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in anterograde axonal protein transport	IMP IMP: Inferred from mutant phenotype	21775604	RGD
involved in axon development	IMP IMP: Inferred from mutant phenotype	23576431	RGD
involved in axon regeneration	IMP IMP: Inferred from mutant phenotype	25944905	RGD
involved in neuron projection development	IEP IEP: Inferred from expression pattern	15033528	RGD
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	21076496	RGD
involved in positive regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	17188238	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	21775604	RGD
located in cell body	IDA IDA: Inferred from direct assay	23576431	RGD
located in dendrite	IDA IDA: Inferred from direct assay	21775604	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21775604	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

C-Jun-amino-terminal kinase-interacting protein 3

JNK MAP kinase scaffold protein 3	JNK-interacting protein 3
JNK/SAPK-associated protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08126	MAPK8IP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mapk8ip3	NCBI	NCBI:23162

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