Mapk8ip3 - mitogen-activated protein kinase 8 interacting protein 3 Gene

Also Known as JIP3; JIP-3; JSAP1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 302983

Summary

Enables mitogen-activated protein kinase kinase binding activity. Involved in several processes, including anterograde axonal protein transport; axon regeneration; and positive regulation of JNK cascade. Located in several cellular components, including cell body; dendrite; and perinuclear region of cytoplasm. Orthologous to human MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Mapk8ip3 Products (1)

mRNA Protein Name
NM_001100673.2 NP_001094143.2 C-Jun-amino-terminal kinase-interacting protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mitogen-activated protein kinase kinase binding IPI
IPI: Inferred from physical interaction
16805806 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
21076496 RGD
Biological Process GO Annotation Evidence References Source
involved in anterograde axonal protein transport IMP
IMP: Inferred from mutant phenotype
21775604 RGD
involved in axon development IMP
IMP: Inferred from mutant phenotype
23576431 RGD
involved in axon regeneration IMP
IMP: Inferred from mutant phenotype
25944905 RGD
involved in neuron projection development IEP
IEP: Inferred from expression pattern
15033528 RGD
involved in positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
21076496 RGD
involved in positive regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
17188238 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
21775604 RGD
located in cell body IDA
IDA: Inferred from direct assay
23576431 RGD
located in dendrite IDA
IDA: Inferred from direct assay
21775604 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
21775604 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-Jun-amino-terminal kinase-interacting protein 3

  • JNK MAP kinase scaffold protein 3

  • JNK-interacting protein 3

  • JNK/SAPK-associated protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08126 MAPK8IP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk8ip3 NCBI NCBI:23162