Rnf216 - ring finger protein 216 Gene

Also Known as RGD1565135

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 304294

Summary

Predicted to enable ubiquitin protein Ligase activity. Involved in protein catabolic process, modulating synaptic transmission. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic endocytic zone. Human ortholog(s) of this gene implicated in Gordon Holmes syndrome. Orthologous to human RNF216 (ring finger protein 216). [provided by Alliance of Genome Resources, Apr 2022]

Rnf216 Products (1)

mRNA Protein Name
NM_001107122.1 NP_001100592.1 E3 ubiquitin-protein ligase RNF216

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in protein catabolic process, modulating synaptic transmission IDA
IDA: Inferred from direct assay
24945773 RGD
involved in protein catabolic process, modulating synaptic transmission IMP
IMP: Inferred from mutant phenotype
24945773 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
24945773 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
24945773 RGD
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
24945773 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24945773 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
24945773 RGD
is active in postsynaptic endocytic zone IDA
IDA: Inferred from direct assay
24945773 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
24945773 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF216

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12080 RNF216 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rnf216 NCBI NCBI:54476