2. Gene
  3. ERCC4 - Ercc4 ERCC excision repair 4, endonuclease catalytic subunit Gene

ERCC4 - Ercc4 ERCC excision repair 4, endonuclease catalytic subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1560340

Gene ID: 304719 | Gene type: protein coding

About ERCC4

Summary

Predicted to enable several functions, including DNA binding activity; TFIID-class transcription factor complex binding activity; and promoter-specific chromatin binding activity. Predicted to contribute to 3' overhang single-stranded DNA endodeoxyribonuclease activity and DNA binding activity. Involved in cellular response to organic cyclic compound. Predicted to be located in chromosome, telomeric region and nucleus. Predicted to be part of ERCC4-ERCC1 complex and nucleotide-excision repair factor 1 complex. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group Q; XFE progeroid syndrome; pancreatic cancer; xeroderma pigmentosum; and xeroderma pigmentosum group F. Orthologous to human ERCC4 (ERCC excision repair 4, Endonuclease catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]

ERCC4 Products(5)

mRNA Protein Name
XM_039087014.1 XP_038942942.1 DNA repair endonuclease XPF isoform X1
XM_039087016.1 XP_038942944.1 DNA repair endonuclease XPF isoform X3
XM_039087015.1 XP_038942943.1 DNA repair endonuclease XPF isoform X2
XM_039087017.1 XP_038942945.1 DNA repair endonuclease XPF isoform X4
XM_039087018.1 XP_038942946.1 DNA repair endonuclease XPF isoform X5
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
20101267 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA repair endonuclease XPF

excision repair cross-complementing rodent repair deficiency, complementation group 4

Ercc4 protein-like

excision repair cross-complementation group 4

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04481 ERCC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ERCC4 NCBI NCBI:2072