Mthfd2l - methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like Gene

Rattus norvegicus

Also known as RGD1310879

Gene ID: 305248 | Gene type: protein coding

About Mthfd2l

Summary

Enables methylenetetrahydrofolate dehydrogenase (NADP+) activity. Involved in 10-formyltetrahydrofolate metabolic process and tetrahydrofolate interconversion. Located in mitochondrial inner membrane and mitochondrial matrix. Orthologous to human MTHFD2L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like). [provided by Alliance of Genome Resources, Apr 2022]

Mthfd2l Products(1)

mRNA	Protein	Name
NM_001107211.2	NP_001100681.1	bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables methenyltetrahydrofolate cyclohydrolase activity	IDA IDA: Inferred from direct assay	24733394	RGD
NOT enables methylenetetrahydrofolate dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	24733394	RGD
enables methylenetetrahydrofolate dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	24733394	RGD
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity	IDA IDA: Inferred from direct assay	21163947	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in 10-formyltetrahydrofolate metabolic process	IDA IDA: Inferred from direct assay	21163947	RGD
involved in tetrahydrofolate interconversion	IDA IDA: Inferred from direct assay	21163947	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	21163947	RGD
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	21163947	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial

probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2

MTHFD2-like	NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein
methylenetetrahydrofolate dehydrogenase 2-like

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-155219	TH9028	Inhibitor	/	Unkown
HY-RS08777	MTHFD2L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-148014	TH7299		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mthfd2l	NCBI	NCBI:441024

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