OTX2 - Otx2 orthodenticle homeobox 2 Gene

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including neuron differentiation; positive regulation of gastrulation; and regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; nervous system development; and regionalization. Predicted to be located in cytoplasm and growth cone. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in panhypopituitarism and syndromic microphthalmia 5. Orthologous to human OTX2 (orthodenticle homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]