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ZNF354C - zinc finger protein 354C Gene

Also Known as KID3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 30832

About ZNF354C

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:179,060,373-179,083,977 (from NCBI)

This gene has 1 transcript (splice variant), 75 orthologues and 174 paralogues. Ubiquitous expression in ovary (RPKM 3.8), thyroid (RPKM 3.7) and 25 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZNF354C Products (1)

mRNA	Protein	Name
NM_014594.3	NP_055409.1	zinc finger protein 354C

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	33154469	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	33154469	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	33154469	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	33154469	GOA
located in nuclear membrane	IDA IDA: Inferred from direct assay	33154469	GOA
located in nucleus	IDA IDA: Inferred from direct assay	33154469	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF354C Protein Structure

KRAB

zf-H2C2_2

0
100
200
300
400
500
554 a.a.

Protein Preferred Names	Protein Names
zinc finger protein 354C	KRAB-zinc finger protein synten

Related Diseases

Diseases	Alias
Paraphimosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16130	ZNF354C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZNF354C	VGNC	VGNC:108152
Mus musculus	ZNF354C	MGD	MGI:1353621
Bos taurus	ZNF354C	VGNC	VGNC:37256
Rattus norvegicus	ZNF354C	RGD	RGD:69405
Others	ZNF354C	NCBI