Zbtb18 - zinc finger and BTB domain containing 18 Gene

Mus musculus

Also known as RP58; Zfp238; Znf238.; zfp-238

Gene ID: 30928 | Gene type: protein coding

About Zbtb18

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated and skeletal muscle tissue development. Acts upstream of or within several processes, including in utero embryonic development; negative regulation of transcription by RNA polymerase II; and nervous system development. Located in nucleus. Is expressed in several structures, including genitourinary system; limb; nervous system; sensory organ; and skeleton. Used to study autosomal dominant non-syndromic intellectual disability. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 22. Orthologous to human ZBTB18 (zinc finger and BTB domain containing 18). [provided by Alliance of Genome Resources, Apr 2022]

Zbtb18 Products(8)

mRNA	Protein	Name
NM_001012330.1	NP_001012330.1	zinc finger and BTB domain-containing protein 18 isoform 1
NM_001355098.1	NP_001342027.1	zinc finger and BTB domain-containing protein 18 isoform 1
NM_001355099.1	NP_001342028.1	zinc finger and BTB domain-containing protein 18 isoform 2
NM_001355100.1	NP_001342029.1	zinc finger and BTB domain-containing protein 18 isoform 2
NM_001355101.1	NP_001342030.1	zinc finger and BTB domain-containing protein 18 isoform 2
NM_001355102.1	NP_001342031.1	zinc finger and BTB domain-containing protein 18 isoform 2
NM_001355103.1	NP_001342032.1	zinc finger and BTB domain-containing protein 18 isoform 3
NM_013915.3	NP_038943.3	zinc finger and BTB domain-containing protein 18 isoform 2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cerebellum development	IMP IMP: Inferred from mutant phenotype	19409883	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	19409883	MGI
acts upstream of or within hippocampus development	IMP IMP: Inferred from mutant phenotype	19409883	MGI
acts upstream of or within homeostasis of number of cells	IMP IMP: Inferred from mutant phenotype	19409883	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	19409883	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20059953	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18262495	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20059953	MGI
acts upstream of or within neuron development	IMP IMP: Inferred from mutant phenotype	19409883	MGI
acts upstream of or within regulation of cell division	IMP IMP: Inferred from mutant phenotype	19409883	MGI
involved in skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	20059953	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	18262495	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

zinc finger and BTB domain-containing protein 18

58 kDa repressor protein	transcriptional repressor RP58
zinc finger protein 238

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15966	ZBTB18 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zbtb18	NCBI	NCBI:10472

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