2. Gene
  3. OPHN1 - Ophn1 oligophrenin 1 Gene

OPHN1 - Ophn1 oligophrenin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Opn1

Gene ID: 312108 | Gene type: protein coding

About OPHN1

Summary

Enables ionotropic glutamate receptor binding activity. Involved in maintenance of postsynaptic specialization structure. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in X-linked mental retardation with cerebellar hypoplasia and distinctive facial appearance. Orthologous to human OPHN1 (oligophrenin 1). [provided by Alliance of Genome Resources, Apr 2022]

OPHN1 Products(2)

mRNA Protein Name
NM_001107848.1 NP_001101318.1 oligophrenin-1
NM_001107848.1 NP_001101318.1 oligophrenin-1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
19487570 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
21874017 RGD
Biological Process GO Annotation Evidence Reference Source
involved in maintenance of postsynaptic specialization structure EXP
EXP: Inferred from Experiment
24966368 RGD
involved in maintenance of postsynaptic specialization structure IDA
IDA: Inferred from direct assay
24966368 RGD
involved in maintenance of postsynaptic specialization structure IMP
IMP: Inferred from mutant phenotype
24966368 RGD
involved in regulation of synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
19481455 RGD
involved in regulation of synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
19481455 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
24966368 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24966368 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
24966368 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
15034583 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

oligophrenin-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09793 OPHN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens OPHN1 NCBI NCBI:4983