2. Gene
  3. Whrn - whirlin Gene

Whrn - whirlin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Cip98; Dfnb31

Gene ID: 313255 | Gene type: protein coding

About Whrn

Summary

Enables protein domain specific binding activity. Predicted to be involved in several processes, including detection of mechanical stimulus involved in sensory perception of sound; nervous system development; and paranodal junction maintenance. Predicted to act upstream of or within establishment of protein localization and positive regulation of gene expression. Located in several cellular components, including dendrite; stereocilia ankle link; and stereocilium tip. Colocalizes with neuronal cell body; photoreceptor connecting cilium; and photoreceptor inner segment. Human ortholog(s) of this gene implicated in Usher syndrome type 2D; autosomal recessive nonsyndromic deafness 31; and sensorineural hearing loss. Orthologous to human WHRN (whirlin). [provided by Alliance of Genome Resources, Apr 2022]

Whrn Products(2)

mRNA Protein Name
NM_001389267.1 NP_001376196.1 whirlin isoform 2
NM_181088.2 NP_851602.2 whirlin isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
12641734 RGD
Cellular Component GO Annotation Evidence Reference Source
located in apical dendrite IDA
IDA: Inferred from direct assay
12641734 RGD
located in axon collateral IDA
IDA: Inferred from direct assay
12641734 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
12641734 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12641734 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12641734 RGD
located in photoreceptor connecting cilium IDA
IDA: Inferred from direct assay
16434480 RGD
located in photoreceptor inner segment IDA
IDA: Inferred from direct assay
16434480 RGD
located in postsynapse IDA
IDA: Inferred from direct assay
12641734 RGD
located in presynapse IDA
IDA: Inferred from direct assay
12641734 RGD
located in stereocilia ankle link IDA
IDA: Inferred from direct assay
23055499 RGD
located in stereocilium IDA
IDA: Inferred from direct assay
16434480 RGD
located in stereocilium tip IDA
IDA: Inferred from direct assay
23055499 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

whirlin

CASK-interacting protein CIP98

deafness, autosomal recessive 31

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15815 WHRN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Whrn NCBI NCBI:25861