Mlh3 - mutL homolog 3 Gene

Predicted to enable ATP hydrolysis activity; centromeric DNA binding activity; and chromatin binding activity. Predicted to be involved in mismatch repair. Predicted to act upstream of or within cellular response to DNA damage stimulus; meiotic nuclear division; and protein localization. Predicted to be located in male germ cell nucleus and nuclear lumen. Predicted to be part of mismatch repair complex. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal cancer; endometrial cancer; and hereditary nonpolyposis colorectal Cancer type 7. Orthologous to human MLH3 (mutL homolog 3). [provided by Alliance of Genome Resources, Apr 2022]