2. Gene
  3. Mlc1 - modulator of VRAC current 1 Gene

Mlc1 - modulator of VRAC current 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 315215 | Gene type: protein coding

About Mlc1

Summary

Predicted to enable identical protein binding activity. Involved in caveolin-mediated endocytosis; cellular response to cholesterol; and protein transport. Located in several cellular components, including caveola; endosome; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in megalencephalic leukoencephalopathy with subcortical cysts 1. Orthologous to human MLC1 (modulator of VRAC current 1). [provided by Alliance of Genome Resources, Apr 2022]

Mlc1 Products(1)

mRNA Protein Name
NM_001108105.1 NP_001101575.1 membrane protein MLC1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in caveolin-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
19931615 RGD
involved in cellular response to cholesterol IDA
IDA: Inferred from direct assay
19931615 RGD
involved in protein transport IDA
IDA: Inferred from direct assay
19931615 RGD
involved in vesicle-mediated transport IDA
IDA: Inferred from direct assay
19931615 RGD
Cellular Component GO Annotation Evidence Reference Source
located in caveola IDA
IDA: Inferred from direct assay
19931615 RGD
NOT located in clathrin-coated vesicle IDA
IDA: Inferred from direct assay
19931615 RGD
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
19931615 RGD
located in early endosome IDA
IDA: Inferred from direct assay
19931615 RGD
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
19931615 RGD
located in lysosome IDA
IDA: Inferred from direct assay
19931615 RGD
located in membrane raft IDA
IDA: Inferred from direct assay
19931615 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
19931615 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
19931615 RGD
located in recycling endosome IDA
IDA: Inferred from direct assay
19931615 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

membrane protein MLC1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08485 MLC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08909 MYL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mlc1 NCBI NCBI:23209