Myo6 - myosin VI Gene

Also Known as RGD1560646

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 315840

Summary

Predicted to enable several functions, including ADP binding activity; actin filament binding activity; and Calmodulin binding activity. Involved in response to xenobiotic stimulus. Located in several cellular components, including endocytic vesicle; microvillus; and ruffle membrane. Part of protein-containing complex. Used to study hypertension. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (Myosin VI). [provided by Alliance of Genome Resources, Apr 2022]

Myo6 Products (4)

mRNA Protein Name
XM_008766423.2 XP_008764645.1 unconventional myosin-VI isoform X1
XM_039082536.1 XP_038938464.1 unconventional myosin-VI isoform X2
XM_008766425.3 XP_008764647.1 unconventional myosin-VI isoform X3
XM_008766426.2 XP_008764648.1 unconventional myosin-VI isoform X4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15505042 RGD
Biological Process GO Annotation Evidence References Source
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
17652375 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
15837803 RGD
located in apical part of cell IDA
IDA: Inferred from direct assay
11934687 RGD
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
15837803 RGD
located in endocytic vesicle IDA
IDA: Inferred from direct assay
15355515 RGD
located in microvillus IDA
IDA: Inferred from direct assay
18653479 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
12050163 RGD
located in ruffle membrane IDA
IDA: Inferred from direct assay
9852149 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

unconventional myosin-VI

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08949 MYO6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myo6 NCBI NCBI:4646