Syne2 - spectrin repeat containing, nuclear envelope 2 Gene

Mus musculus

Also known as NUA; dice; Cpfl8; KASH2; Nesp2g; mKIAA1011; D12Ertd777e; 6820443O06Rik

Gene ID: 319565 | Gene type: protein coding

About Syne2

Summary

Enables actin binding activity. Involved in several processes, including centrosome localization; nuclear migration; and regulation of cilium assembly. Acts upstream of or within several processes, including fibroblast migration; nuclear envelope organization; and protein localization to nucleus. Located in Z disc and nuclear outer membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant Emery-Dreifuss muscular dystrophy 5. Orthologous to human SYNE2 (spectrin repeat containing nuclear envelope protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Syne2 Products(2)

mRNA	Protein	Name
NM_001005510.2	NP_001005510.2	nesprin-2
NM_001005510.2	NP_001005510.2	nesprin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IDA IDA: Inferred from direct assay	20724637	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	24880667	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in centrosome localization	IMP IMP: Inferred from mutant phenotype	19596800	MGI
involved in nuclear migration along microfilament	IMP IMP: Inferred from mutant phenotype	20724637	MGI
involved in nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration	IMP IMP: Inferred from mutant phenotype	19874786	MGI
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20724637	MGI
involved in regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	19596800	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Z disc	IDA IDA: Inferred from direct assay	15671068	MGI
located in myofibril	IDA IDA: Inferred from direct assay	15671068	MGI
located in nuclear envelope	IDA IDA: Inferred from direct assay	15671068	MGI
located in nuclear membrane	IDA IDA: Inferred from direct assay	22349700	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nesprin-2

KASH domain-containing protein 2	diminished cone electroretinogram
nesprin 2	nuance
nuclear envelope spectrin repeat protein 2	nucleus and actin connecting element protein
synaptic nuclear envelope 2	synaptic nuclear envelope protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14086	SYNE2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Syne2	NCBI	NCBI:23224

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