Syne2 - spectrin repeat containing, nuclear envelope 2 Gene

Also Known as NUA; dice; Cpfl8; KASH2; Nesp2g; mKIAA1011; D12Ertd777e; 6820443O06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 319565

Summary

Enables actin binding activity. Involved in several processes, including centrosome localization; nuclear migration; and regulation of cilium assembly. Acts upstream of or within several processes, including fibroblast migration; nuclear envelope organization; and protein localization to nucleus. Located in Z disc and nuclear outer membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant Emery-Dreifuss muscular dystrophy 5. Orthologous to human SYNE2 (spectrin repeat containing nuclear envelope protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Syne2 Products (2)

mRNA Protein Name
NM_001005510.2 NP_001005510.2 nesprin-2
NM_001005510.2 NP_001005510.2 nesprin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
20724637 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24880667 MGI
Biological Process GO Annotation Evidence References Source
involved in centrosome localization IMP
IMP: Inferred from mutant phenotype
19596800 MGI
involved in nuclear migration along microfilament IMP
IMP: Inferred from mutant phenotype
20724637 MGI
involved in nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration IMP
IMP: Inferred from mutant phenotype
19874786 MGI
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
20724637 MGI
involved in regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
19596800 MGI
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
15671068 MGI
located in myofibril IDA
IDA: Inferred from direct assay
15671068 MGI
located in nuclear envelope IDA
IDA: Inferred from direct assay
15671068 MGI
located in nuclear membrane IDA
IDA: Inferred from direct assay
22349700 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nesprin-2

  • KASH domain-containing protein 2

  • diminished cone electroretinogram

  • nesprin 2

  • nuance

  • nuclear envelope spectrin repeat protein 2

  • nucleus and actin connecting element protein

  • synaptic nuclear envelope 2

  • synaptic nuclear envelope protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14086 SYNE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Syne2 NCBI NCBI:23224