Enpp6 - ectonucleotide pyrophosphatase/phosphodiesterase 6 Gene

Also Known as Npp6; E-NPP 6; GPC-Cpde; D8Ertd514e; 4833421B01Rik; B830047L21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 320981

Summary

This gene encodes a member of the nucleotide pyrophosphatase/phosphodiesterase family of Enzymes that play an important role in regulating extracellular nucleotide metabolism. The encoded preproprotein undergoes proteolytic processing to generate a glycosylphosphatidylinositol (GPI)-anchored membrane protein that hydrolyzes choline-containing lysophospholipids such as glycerophosphocholine. Mice lacking the encoded protein develop fatty liver and myelin sheath abnormalities. [provided by RefSeq, Jul 2016]

Enpp6 Products (1)

mRNA Protein Name
NM_177304.4 NP_796278.1 glycerophosphocholine cholinephosphodiesterase ENPP6 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glycerophosphocholine cholinephosphodiesterase activity IMP
IMP: Inferred from mutant phenotype
26888014 MGI
enables glycerophosphodiester phosphodiesterase activity IDA
IDA: Inferred from direct assay
15788404 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within choline metabolic process IDA
IDA: Inferred from direct assay
15788404 MGI
involved in choline metabolic process IMP
IMP: Inferred from mutant phenotype
26888014 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
15788404 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glycerophosphocholine cholinephosphodiesterase ENPP6

  • choline-specific glycerophosphodiester phosphodiesterase

  • ectonucleotide pyrophosphatase/phosphodiesterase family member 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04392 ENPP6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Enpp6 NCBI NCBI:133121