2. Gene
  3. Enpp6 - ectonucleotide pyrophosphatase/phosphodiesterase 6 Gene

Enpp6 - ectonucleotide pyrophosphatase/phosphodiesterase 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Npp6; E-NPP 6; GPC-Cpde; D8Ertd514e; 4833421B01Rik; B830047L21Rik

Gene ID: 320981 | Gene type: protein coding

About Enpp6

Summary

This gene encodes a member of the nucleotide pyrophosphatase/phosphodiesterase family of Enzymes that play an important role in regulating extracellular nucleotide metabolism. The encoded preproprotein undergoes proteolytic processing to generate a glycosylphosphatidylinositol (GPI)-anchored membrane protein that hydrolyzes choline-containing lysophospholipids such as glycerophosphocholine. Mice lacking the encoded protein develop fatty liver and myelin sheath abnormalities. [provided by RefSeq, Jul 2016]

Enpp6 Products(1)

mRNA Protein Name
NM_177304.4 NP_796278.1 glycerophosphocholine cholinephosphodiesterase ENPP6 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables glycerophosphocholine cholinephosphodiesterase activity IMP
IMP: Inferred from mutant phenotype
26888014 MGI
enables glycerophosphodiester phosphodiesterase activity IDA
IDA: Inferred from direct assay
15788404 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within choline metabolic process IDA
IDA: Inferred from direct assay
15788404 MGI
involved in choline metabolic process IMP
IMP: Inferred from mutant phenotype
26888014 MGI
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
15788404 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glycerophosphocholine cholinephosphodiesterase ENPP6

choline-specific glycerophosphodiester phosphodiesterase

ectonucleotide pyrophosphatase/phosphodiesterase family member 6

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04392 ENPP6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Enpp6 NCBI NCBI:133121