2. Gene
  3. Rfx6 - regulatory factor X, 6 Gene

Rfx6 - regulatory factor X, 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Rfxdc1; 4930572O07Rik

Gene ID: 320995 | Gene type: protein coding

About Rfx6

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in endocrine pancreas development; glucose homeostasis; and regulation of Insulin secretion. Located in nucleus. Is expressed in several structures, including gut; limb; liver; male reproductive gland or organ; and sensory organ. Orthologous to human RFX6 (regulatory factor X6). [provided by Alliance of Genome Resources, Apr 2022]

Rfx6 Products(2)

mRNA Protein Name
NM_001159389.1 NP_001152861.1 DNA-binding protein RFX6 isoform 1
NM_177306.3 NP_796280.1 DNA-binding protein RFX6 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20148032 MGI
Biological Process GO Annotation Evidence Reference Source
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
20148032 MGI
involved in pancreatic A cell differentiation IMP
IMP: Inferred from mutant phenotype
20148032 MGI
involved in pancreatic D cell differentiation IMP
IMP: Inferred from mutant phenotype
20148032 MGI
involved in pancreatic epsilon cell differentiation IMP
IMP: Inferred from mutant phenotype
20148032 MGI
involved in regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
20148032 MGI
involved in type B pancreatic cell differentiation IMP
IMP: Inferred from mutant phenotype
20148032 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
20148032 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA-binding protein RFX6

regulatory factor X domain containing 1

regulatory factor X domain-containing protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11884 RFX6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rfx6 NCBI NCBI:222546