Zfp335 - zinc finger protein 335 Gene

Also Known as Nif1; NIF-1; Znf335; 1810045J01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 329559

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in brain development and positive regulation of neuroblast proliferation. Acts upstream of or within several processes, including in utero embryonic development; nervous system development; and regulation of histone H3-K4 methylation. Located in nucleus. Part of Histone Methyltransferase complex. Is expressed in brain and future brain. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 10. Orthologous to human ZNF335 (Zinc Finger Protein 335). [provided by Alliance of Genome Resources, Apr 2022]

Zfp335 Products (1)

mRNA Protein Name
NM_199027.2 NP_950192.2 zinc finger protein 335

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23178126 MGI
enables histone methyltransferase binding IDA
IDA: Inferred from direct assay
23178126 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23178126 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
23178126 MGI
Biological Process GO Annotation Evidence References Source
involved in brain development IMP
IMP: Inferred from mutant phenotype
23178126 MGI
acts upstream of or within brain morphogenesis IGI
IGI: Inferred from genetic interaction
23178126 MGI
acts upstream of or within brain morphogenesis IMP
IMP: Inferred from mutant phenotype
23178126 MGI
acts upstream of or within cerebral cortex neuron differentiation IGI
IGI: Inferred from genetic interaction
23178126 MGI
acts upstream of or within cerebral cortex neuron differentiation IMP
IMP: Inferred from mutant phenotype
23178126 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
23178126 MGI
acts upstream of or within neuron projection morphogenesis IMP
IMP: Inferred from mutant phenotype
23178126 MGI
involved in neuron projection morphogenesis IMP
IMP: Inferred from mutant phenotype
23178126 MGI
involved in positive regulation of neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
23178126 MGI
acts upstream of or within regulation of gene expression IDA
IDA: Inferred from direct assay
23178126 MGI
acts upstream of or within regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
23178126 MGI
Cellular Component GO Annotation Evidence References Source
part of histone methyltransferase complex IDA
IDA: Inferred from direct assay
23178126 MGI
located in nucleus IDA
IDA: Inferred from direct assay
23178126 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger protein 335

  • NRC-interacting factor 1