Piwil4 - piwi-like RNA-mediated gene silencing 4 Gene

Also Known as Miwi2; mAgo5; 9230101H05Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 330890

Summary

Enables piRNA binding activity. Involved in gamete generation; gene silencing by RNA; and piRNA metabolic process. Acts upstream of or within negative regulation of transposition. Located in nucleus and piP-body. Is expressed in embryo; germ cell of testis; testis; and trunk unsegmented mesenchyme. Orthologous to human PIWIL4 (piwi like RNA-mediated gene silencing 4). [provided by Alliance of Genome Resources, Apr 2022]

Piwil4 Products (3)

mRNA	Protein	Name
NM_001368831.1	NP_001355760.1	piwi-like protein 4 isoform 1
NM_001368832.1	NP_001355761.1	piwi-like protein 4 isoform 2
NM_001368836.1	NP_001355765.1	piwi-like protein 4 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
NOT enables RNA endonuclease activity	IMP IMP: Inferred from mutant phenotype	22020280	MGI
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	33020597	MGI
enables piRNA binding	IDA IDA: Inferred from direct assay	18922463	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16787967	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in piRNA processing	IDA IDA: Inferred from direct assay	26669262	MGI
involved in piRNA processing	IMP IMP: Inferred from mutant phenotype	17395546	MGI
involved in piRNA-mediated gene silencing by mRNA destabilization	IMP IMP: Inferred from mutant phenotype	29437694	MGI
acts upstream of or within retrotransposon silencing by heterochromatin formation	IMP IMP: Inferred from mutant phenotype	25503965	MGI
acts upstream of positive effect retrotransposon silencing by heterochromatin formation	IMP IMP: Inferred from mutant phenotype	22020280	MGI
involved in retrotransposon silencing by mRNA destabilization	IMP IMP: Inferred from mutant phenotype	18922463	MGI
involved in retrotransposon silencing by piRNA-directed DNA methylation	IMP IMP: Inferred from mutant phenotype	18381894	MGI
involved in retrotransposon silencing by piRNA-directed DNA methylation	IPI IPI: Inferred from physical interaction	32674113	MGI
involved in secondary piRNA processing	IDA IDA: Inferred from direct assay	18922463	MGI
involved in secondary piRNA processing	IMP IMP: Inferred from mutant phenotype	29437694	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	25503965	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	17395546	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in P granule	IDA IDA: Inferred from direct assay	18922463	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	18922463	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18922463	MGI
located in piP-body	IDA IDA: Inferred from direct assay	20011505	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
piwi-like protein 4	piwi-like 4 piwi-like homolog 4

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10587	PIWIL4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Piwil4	NCBI	NCBI:143689