HTR1F - 5-hydroxytryptamine receptor 1F Gene

Also Known as 5HT6; MR77; 5-HT1F; HTR1EL; 5-HT-1F

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3355

About HTR1F

Cytogenetic location: 3p11.2-p11.1 Genomic coordinates (GRCh38): 3:87,792,706-87,993,839 (from NCBI)

This gene has 1 transcript (splice variant), 147 orthologues and 8 paralogues. Low expression observed in reference dataset.

Summary

Enables G protein-coupled serotonin receptor activity and serotonin binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

HTR1F Products (4)

mRNA Protein Name
NM_000866.5 NP_000857.1 5-hydroxytryptamine receptor 1F
NM_001322208.2 NP_001309137.1 5-hydroxytryptamine receptor 1F
NM_001322209.2 NP_001309138.1 5-hydroxytryptamine receptor 1F
NM_001322210.2 NP_001309139.1 5-hydroxytryptamine receptor 1F

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled serotonin receptor activity IDA
IDA: Inferred from direct assay
8380639 GOA
enables G protein-coupled serotonin receptor activity IMP
IMP: Inferred from mutant phenotype
21422162 GOA
enables Gi/o-coupled serotonin receptor activity IDA
IDA: Inferred from direct assay
34239069 GOA
enables serotonin binding IDA
IDA: Inferred from direct assay
8380639 GOA
enables serotonin receptor activity IDA
IDA: Inferred from direct assay
34239069 GOA
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21422162 GOA
involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA
IDA: Inferred from direct assay
34239069 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
21422162 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTR1F Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (41 - 347)

  • 0
  • 100
  • 200
  • 300
  • 366 a.a.
Protein Preferred Names Protein Names

5-hydroxytryptamine receptor 1F

  • 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled

HTR1F Antibodies

Cat. No. Product Name Application Reactivity
HY-P86758 5-HT (Serotonin) Antibody (YA6451) WB, IHC-P, IF-Tissue, IHC-F, ELISA Species independent

Related Diseases

Diseases Alias
Migraine With Or Without Aura 1

  • Migraine

  • Migraine With Or Without Aura, Susceptibility To, 1

  • Migraine Disorder

  • Migraine Variant

  • Migraines

  • Migraine Disorders

  • Mgr1

  • Mgau

  • Ma

  • Migraine With Or Without Aura

  • Classic Migraine

  • Common Migraine

  • Disorder, Migraine

  • Headache Migraine

  • Headache Migrainous

  • Migraine Headache

  • Migraine Syndrome

  • Headache Including Migraine

  • Migraine, Susceptibility To
Intracranial Vasospasm

  • Vasospasm, Intracranial
Tolosa-Hunt Syndrome

  • Painful Ophthalmoplegia

  • Tolosa Hunt Syndrome

  • Nonspecific Inflammation Of The Cavernous Sinus Or Superior Orbital Fissure

  • Ths

  • Ophthalmoplegia, Painful
Dyslexia
Migraine With Aura

  • Classic Migraine

  • Migraine With Typical Aura

  • Migraine Accompagnée

  • Complicated Migraine

  • Classical Migraine

  • Acute Migraine With Aura
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06464 HTR1F Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HTR1F RGD RGD:71083
Canis familiaris HTR1F VGNC VGNC:41826
Bos taurus HTR1F VGNC VGNC:29995
Felis catus HTR1F VGNC VGNC:67671
Mus musculus HTR1F MGD MGI:99842
Others HTR1F NCBI