BRINP3 - BMP/retinoic acid inducible neural specific 3 Gene

Also Known as FAM5C; DBCCR1L; DBCCR1L1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 339479

About BRINP3

Cytogenetic location: 1q31.1 Genomic coordinates (GRCh38): 1:190,097,658-190,477,864 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues and 2 paralogues. Biased expression in brain (RPKM 4.5), small intestine (RPKM 2.0) and 6 other tissues.

Summary

This gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric Cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

BRINP3 Products (2)

mRNA Protein Name
NM_001317188.2 NP_001304117.1 BMP/retinoic acid-inducible neural-specific protein 3 isoform 2
NM_199051.3 NP_950252.1 BMP/retinoic acid-inducible neural-specific protein 3 isoform 1 precursor

BRINP3 Protein Structure

MACPF

MACPF: MAC/Perforin domain (53 - 173)

  • 0
  • 200
  • 400
  • 600
  • 766 a.a.
Protein Preferred Names Protein Names

BMP/retinoic acid-inducible neural-specific protein 3

  • DBCCR1-like protein 1

Related Diseases

Diseases Alias
Tongue Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Tongue
Myocardial Infarction

  • Heart Attack

  • Myocardial Infarction, Susceptibility To

  • Myocardial Infarction 1

  • Myocardial Infarction, Protection Against

  • Myocardial Infarction, Decreased Susceptibility To

  • Myocardial Infarction, Decreased

  • Myocardial Infarct

  • MCI1

  • Premature Myocardial Infarction

  • Myocardial Infarction, Susceptibility To, Type 1
Aggressive Periodontitis

  • Juvenile Periodontitis

  • Periodontitis, Juvenile

  • Prepubertal Periodontitis
Colitis
Optic Nerve Glioma

  • Glioma Of The Optic Nerve
Optic Nerve Neoplasm

  • Optic Nerve Neoplasms

  • Neoplasm Of Optic Nerve

  • Tumor Of Second Cranial Nerve

  • Tumour Of Optic Nerve
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01622 BRINP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus BRINP3 VGNC VGNC:60176
Macaca mulatta BRINP3 VGNC VGNC:70363
Bos taurus BRINP3 VGNC VGNC:26568
Canis familiaris BRINP3 VGNC VGNC:38529
Mus musculus BRINP3 MGD MGI:2443035
Rattus norvegicus BRINP3 RGD RGD:708421
Others BRINP3 NCBI