IDI1 - isopentenyl-diphosphate delta isomerase 1 Gene

Also Known as IPP1; IPPI1

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 3422

About IDI1

Cytogenetic location: 10p15.3 Genomic coordinates (GRCh38): 10:1,039,152-1,056,704 (from NCBI)

This gene has 6 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 23.9), brain (RPKM 23.0) and 25 other tissues.

Summary

IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, Cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. [provided by RefSeq, Jul 2008]

IDI1 Products (4)

mRNA Protein Name
NM_001317955.2 NP_001304884.1 isopentenyl-diphosphate Delta-isomerase 1 isoform b
NM_001317956.2 NP_001304885.1 isopentenyl-diphosphate Delta-isomerase 1 isoform b
NM_001317957.2 NP_001304886.1 isopentenyl-diphosphate Delta-isomerase 1 isoform c
NM_004508.4 NP_004499.2 isopentenyl-diphosphate Delta-isomerase 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables isopentenyl-diphosphate delta-isomerase activity IDA
IDA: Inferred from direct assay
8806705 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
17250851 GOA
enables manganese ion binding IDA
IDA: Inferred from direct assay
17250851 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in isoprenoid biosynthetic process IDA
IDA: Inferred from direct assay
8806705 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in peroxisome IDA
IDA: Inferred from direct assay
17180682 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IDI1 Protein Structure

NUDIX

NUDIX: NUDIX domain (108 - 256)

  • 0
  • 100
  • 200
  • 284 a.a.
Protein Preferred Names Protein Names

isopentenyl-diphosphate Delta-isomerase 1

  • IPP isomerase 1

関連疾患

Diseases Alias
Zellweger Syndrome

  • Cerebrohepatorenal Syndrome

  • Zellweger Leukodystrophy

  • Zs

  • Congenital Iron Overload

  • Chr

  • Zws

  • Severe Pbd-Zsd

  • Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Neonatal Adrenoleukodystrophy

  • Nald

  • Adrenoleukodystrophy Autosomal Neonatal Form

  • Intermediate Pbd-Zsd

  • Intermediate Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

  • Adrenoleukodystrophy, Autosomal, Neonatal Form

  • Adrenoleukodystrophy Neonatal

  • Adrenoleukodystrophy, Neonatal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS06536 IDI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21355 Idi1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27874 Idi1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta IDI1 VGNC VGNC:73559
Rattus norvegicus IDI1 RGD RGD:621835
Mus musculus IDI1 MGD MGI:2442264
Others IDI1 NCBI