IDI1 - isopentenyl-diphosphate delta isomerase 1 Gene

Homo sapiens

Also known as IPP1; IPPI1

Gene ID: 3422 | Gene type: protein coding

About IDI1

Cytogenetic location: 10p15.3 Genomic coordinates (GRCh38): 10:1,039,152-1,056,704 (from NCBI)

This gene has 6 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 23.9), brain (RPKM 23.0) and 25 other tissues.

Summary

IDI1 encodes a peroxisomally-localized Enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, Cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. [provided by RefSeq, Jul 2008]

IDI1 Products(4)

mRNA	Protein	Name
NM_001317955.2	NP_001304884.1	isopentenyl-diphosphate Delta-isomerase 1 isoform b
NM_001317956.2	NP_001304885.1	isopentenyl-diphosphate Delta-isomerase 1 isoform b
NM_001317957.2	NP_001304886.1	isopentenyl-diphosphate Delta-isomerase 1 isoform c
NM_004508.4	NP_004499.2	isopentenyl-diphosphate Delta-isomerase 1 isoform a

IDI1 Protein Structure

NUDIX

0
100
200
284 a.a.

Protein Preferred Names

Protein Names

isopentenyl-diphosphate Delta-isomerase 1

IPP isomerase 1

Related Diseases

Diseases

Alias

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Neonatal Adrenoleukodystrophy

Nald	Adrenoleukodystrophy Autosomal Neonatal Form
Intermediate Pbd-Zsd	Intermediate Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Adrenoleukodystrophy, Autosomal, Neonatal Form	Adrenoleukodystrophy Neonatal
Adrenoleukodystrophy, Neonatal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06536	IDI1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IDI1	VGNC	VGNC:73559
Rattus norvegicus	IDI1	RGD	RGD:621835
Mus musculus	IDI1	MGD	MGI:2442264