SMTNL2 - smoothelin like 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 342527

About SMTNL2

This gene has 4 transcripts (splice variants), 256 orthologues and 36 paralogues. Biased expression in kidney (RPKM 11.1), prostate (RPKM 2.3) and 8 other tissues.

Summary

Predicted to enable protein Phosphatase 1 binding activity and tropomyosin binding activity. Predicted to be involved in actin Cytoskeleton organization and positive regulation of vasoconstriction. Predicted to be part of filamentous actin. Predicted to be active in I band; M band; and microtubule organizing center. [provided by Alliance of Genome Resources, Apr 2022]

SMTNL2 Products (3)

mRNA	Protein	Name
NM_001114974.2	NP_001108446.1	smoothelin-like protein 2 isoform 1
NM_001375361.1	NP_001362290.1	smoothelin-like protein 2 isoform 3
NM_198501.3	NP_940903.2	smoothelin-like protein 2 isoform 2

SMTNL2 Protein Structure

CH

0
100
200
300
400
461 a.a.

Protein Preferred Names	Protein Names
smoothelin-like protein 2

Related Diseases

Diseases	Alias
Cerebrovascular Benign Neoplasm
Leukodystrophy, Hypomyelinating, 2	Pmld1 Hypomyelinating Leukodystrophy 2 HLD2 Pelizaeus-Merzbacher-Like Disease 1 Pelizaeus-Merzbacher-Like Disease Due To Gjc2 Mutation Pelizaeus-Merzbacher-Like Disease Type 1 Pelizaeus-Merzbacher-Like Disease, 1 Pelizaeus Merzbacher Like Disease Pelizaeus-Merzbacher-Like Disease Pmld - Pelizaeus Merzbacher Like Disease Pelizaeus-Merzbacher-Like Disease Autosomal Recessive Type 1 Pmldar1 Leukodystrophy, Hypomyelinating, Type 2
Papilloma Of Choroid Plexus	Choroid Plexus Papilloma CPP Childhood Choroid Plexus Papilloma Papilloma Choroid Plexus Papilloma, Choroid Plexus Choroid Plexus Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13456	SMTNL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SMTNL2	VGNC	VGNC:77770
Rattus norvegicus	SMTNL2	RGD	RGD:1585960
Canis familiaris	SMTNL2	VGNC	VGNC:46577
Mus musculus	SMTNL2	MGD	MGI:2442764
Bos taurus	SMTNL2	VGNC	VGNC:35037
Felis catus	SMTNL2	VGNC	VGNC:65508
Others	SMTNL2	NCBI