CTU2 - cytosolic thiouridylase subunit 2 Gene

Also Known as MFRG; NCS2; UPF0432; C16orf84

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 348180

About CTU2

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:88,706,503-88,715,396 (from NCBI)

This gene has 10 transcripts (splice variants), 193 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 3.9), brain (RPKM 2.8) and 25 other tissues.

Summary

This gene encodes a protein which is involved in the post-transcriptional modification of transfer RNAs (tRNAs). The encoded protein plays a role in thiolation of uridine residue present at the wobble position in a subset of tRNAs, resulting in enhanced codon reading accuracy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

CTU2 Products (4)

mRNA Protein Name
NM_001012759.3 NP_001012777.1 cytoplasmic tRNA 2-thiolation protein 2 isoform 1
NM_001012762.3 NP_001012780.1 cytoplasmic tRNA 2-thiolation protein 2 isoform 2
NM_001318507.2 NP_001305436.1 cytoplasmic tRNA 2-thiolation protein 2 isoform 3
NM_001318513.2 NP_001305442.1 cytoplasmic tRNA 2-thiolation protein 2 isoform 4

CTU2 Protein Structure

CTU2

CTU2: Cytoplasmic tRNA 2-thiolation protein 2 (271 - 371)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 515 a.a.
Protein Preferred Names Protein Names

cytoplasmic tRNA 2-thiolation protein 2

  • cytosolic thiouridylase subunit 2 homolog

CTU2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86828 CTU2 Antibody (YA6521) WB, IHC-P Human, Mouse, Monkey

Related Diseases

Diseases Alias
Microcephaly, Facial Dysmorphism, Renal Agenesis, And Ambiguous Genitalia Syndrome

  • MFRG
Peroneal Neuropathy

  • Peroneal Neuropathies
Cakut

  • Renal Or Urinary Tract Malformation

  • Congenital Anomalies Of Kidney And Urinary Tract

  • Congenital Anomaly Of Kidney And Urinary Tract

  • Congenital Anomalies Of The Kidney And Urinary Tract

  • Kidney And Urinary Tract, Anomalies, Congenital

  • Renal Hypodysplasia, Nonsyndromic, 1
Phobia, Specific

  • Specific Phobia

  • Simple Phobia

  • Phobia, Simple

  • Isolated Phobia
Primary Microcephaly

  • True Microcephaly

  • Microcephaly, Primary
Dysthymic Disorder

  • Dysthymia

  • Chronic Depressive Disorder

  • Chronic Depression

  • Depressive Personality

  • Depressive Personality Disorder

  • Persistent Depressive Disorder

  • Persistent Depression
Social Phobia

  • Phobia, Social

  • Phobia Social

  • Phobic Anxiety Disorder
Intermittent Explosive Disorder

  • Explosive Personality Disorder
Phobic Disorder

  • Phobic Disorders

  • Phobic Anxiety Disorder
Sucrase-Isomaltase Deficiency, Congenital

  • Congenital Sucrase-Isomaltase Deficiency

  • CSID

  • Si Deficiency

  • Congenital Sucrose Intolerance

  • Disaccharide Intolerance

  • Sucrase-Isomaltase Deficiency

  • Disaccharide Intolerance I

  • Congenital Sucrose-Isomaltose Malabsorption

  • Sucrose-Isomaltose Malabsorption, Congenital

  • Sucrose Intolerance, Congenital

  • Congenital Sucrase-Isomaltose Malabsorption

  • Congenital Sucrose-Isomaltase Malabsorption

  • Disaccharide Intolerance, 1

  • Sucrose Intolerance Congenital

  • Sucrose-Isomaltase Malabsorption, Congenital

  • Disaccharidase Deficiency

  • Invertase Deficiency

  • Sucrase-Alpha-Dextrinase Deficiency

  • Disaccharide Intolerance Type I

  • Csid - [Congenital Sucrase-Isomaltase Deficiency]

  • Sucrose Intolerance Of Newborn

  • Sucrose Intolerance

  • Sucrase Deficiency

  • Disaccharide Malabsorption

  • Intestinal Disaccharidase Deficiency
Hymenolepiasis

  • Dwarf Tapeworm Infection

  • Hymenolepis Infectious Disease

  • Hymenolepsis Infection

  • Hyemolepis Nana Infection

  • Hymenolepiosis

  • Hymenolepis Infection

  • Dwarf Tapeworm

  • Hymenolepidosis

  • Hymenolepis Infestation
Agoraphobia

  • Fear Of Open Spaces

  • Phobia Of Going Out
Separation Anxiety Disorder

  • Separation Anxiety Disorder Of Childhood
Generalized Anxiety Disorder

  • Anxiety Generalized
Lissencephaly

  • Pachygyria

  • Broad Gyri Of Cerebrum

  • Large Gyri Of Cerebrum

  • Macrogyria
Kbg Syndrome

  • KBGS

  • Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies

  • Short Stature, Characteristic Facies, Macrodontia, Intellectual Disability, And Skeletal Anomalies

  • Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies

  • Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome

  • Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03354 CTU2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CTU2 RGD RGD:1562594
Mus musculus CTU2 MGD MGI:1914215
Felis catus CTU2 VGNC VGNC:61276
Canis familiaris CTU2 VGNC VGNC:39721
Bos taurus CTU2 VGNC VGNC:27824
Macaca mulatta CTU2 VGNC VGNC:71598
Others CTU2 NCBI