IGHA2 - immunoglobulin heavy constant alpha 2 (A2m marker) Gene

Also Known as A2M

Species: Homo sapiens

Gene Type: other
Gene ID: 3494

About IGHA2

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:105,586,937-105,588,394 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 87 orthologues and 82 paralogues.

Summary

Contributes to immunoglobulin receptor binding activity. Involved in Antibacterial humoral response; glomerular filtration; and positive regulation of respiratory burst. Located in extracellular space. Part of monomeric IgA immunoglobulin complex and secretory dimeric IgA immunoglobulin complex. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to immunoglobulin receptor binding IDA
IDA: Inferred from direct assay
23250751 GOA
Biological Process GO Annotation Evidence References Source
involved in antibacterial humoral response IDA
IDA: Inferred from direct assay
23250751 GOA
involved in glomerular filtration IMP
IMP: Inferred from mutant phenotype
23398317 GOA
involved in positive regulation of respiratory burst IDA
IDA: Inferred from direct assay
24145934 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
23398317 GOA
part of monomeric IgA immunoglobulin complex IDA
IDA: Inferred from direct assay
23250751 GOA
part of secretory IgA immunoglobulin complex IDA
IDA: Inferred from direct assay
23250751 GOA
part of secretory dimeric IgA immunoglobulin complex IDA
IDA: Inferred from direct assay
24145934 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGHA2 Protein Structure

C1-set

C1-set: Immunoglobulin C1-set domain (19 - 94)

Ig_2

Ig_2: Immunoglobulin domain (126 - 200)

C1-set

C1-set: Immunoglobulin C1-set domain (222 - 308)

  • 0
  • 100
  • 200
  • 300
  • 340 a.a.

Orthologs Information

Species Symbol Source ID
Mus musculus IGHA2 MGD MGI:96444