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Nr1d2 - nuclear receptor subfamily 1, group D, member 2 Gene

Also Known as RVR; Rev-erb

Species: Mus musculus

Gene Type: protein coding

Gene ID: 353187

Summary

This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. [provided by RefSeq, Feb 2014]

Nr1d2 Products (1)

mRNA	Protein	Name
NM_011584.4	NP_035714.3	nuclear receptor subfamily 1 group D member 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	7838156	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	7838156	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11058961	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11058961	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19682428	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11113208	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in circadian behavior	IMP IMP: Inferred from mutant phenotype	29723273	MGI
involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	15623503	MGI
involved in lipid homeostasis	IMP IMP: Inferred from mutant phenotype	15623503	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	23221024	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15623503	MGI
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	29533925	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11058961	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19682428	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	7838158	MGI
involved in regulation of circadian rhythm	IDA IDA: Inferred from direct assay	23221024	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	29533925	MGI
involved in regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	15623503	MGI
involved in regulation of lipid metabolic process	IMP IMP: Inferred from mutant phenotype	15623503	MGI
involved in regulation of skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	15623503	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	29508494	MGI
located in nucleus	IDA IDA: Inferred from direct assay	29508494	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
nuclear receptor subfamily 1 group D member 2	Rev-erb beta orphan nuclear receptor RVR rev-erb-beta

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09528	NR1D2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr1d2	NCBI	NCBI:9975