TICAM2 - TIR domain containing adaptor molecule 2 Gene

Also Known as TIRP; TRAM; TIRAP3; MyD88-4; TICAM-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 353376

About TICAM2

Cytogenetic location: 5q22.3 Genomic coordinates (GRCh38): 5:115,578,496-115,602,479 (from NCBI)

This gene has 2 transcripts (splice variants) and 110 orthologues. Ubiquitous expression in appendix (RPKM 4.0), spleen (RPKM 3.2) and 25 other tissues.

Summary

TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004]

TICAM2 Products (1)

mRNA	Protein	Name
NM_021649.7	NP_067681.1	TIR domain-containing adapter molecule 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	28630139	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17258210	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in TRAM-dependent toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	19412184	GOA
involved in TRAM-dependent toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	22685567	GOA
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	19412184	GOA
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	22685567	GOA
involved in negative regulation of chemokine (C-C motif) ligand 5 production	IMP IMP: Inferred from mutant phenotype	19412184	GOA
involved in negative regulation of toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	19412184	GOA
involved in phagocytosis	IMP IMP: Inferred from mutant phenotype	30883606	GOA
involved in positive regulation of chemokine (C-C motif) ligand 5 production	IMP IMP: Inferred from mutant phenotype	19412184	GOA
involved in positive regulation of interleukin-18-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	22685567	GOA
involved in positive regulation of toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	19412184	GOA
involved in positive regulation of toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	22685567	GOA
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	25385819	GOA
involved in toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	28630139	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in early endosome	IDA IDA: Inferred from direct assay	19412184	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19412184	GOA
is active in endosome	IDA IDA: Inferred from direct assay	28630139	GOA
is active in endosome membrane	IDA IDA: Inferred from direct assay	28630139	GOA
located in late endosome	IDA IDA: Inferred from direct assay	19412184	GOA
located in phagocytic cup	IDA IDA: Inferred from direct assay	30883606	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19412184	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TICAM2 Protein Structure

TIR_2

0
100
200
235 a.a.

Protein Preferred Names	Protein Names
TIR domain-containing adapter molecule 2	NF-kappa-B-activating protein 502

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14518	TICAM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TICAM2	MGD	MGI:3040056
Rattus norvegicus	TICAM2	RGD	RGD:1308258
Bos taurus	TICAM2	VGNC	VGNC:55148
Others	TICAM2	NCBI