Gab1 - GRB2-associated binding protein 1 Gene

Rattus norvegicus

Gene ID: 361388 | Gene type: protein coding

About Gab1

Summary

Involved in response to hepatocyte growth factor. Predicted to be located in cell-cell junction and cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 26. Orthologous to human GAB1 (GRB2 associated binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Gab1 Products(1)

mRNA	Protein	Name
NM_001108444.1	NP_001101914.1	GRB2-associated-binding protein 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16187300	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in response to hepatocyte growth factor	IPI IPI: Inferred from physical interaction	16187300	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

GRB2-associated-binding protein 1

growth factor receptor bound protein 2-associated protein 1

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Rare Diseases
HY-13404	Capmatinib	99.71%	Yes
HY-13404C	Capmatinib dihydrochloride hydrate	99.67%	Yes
HY-13404A	Capmatinib dihydrochloride	99.82%	Yes
HY-13404B	Capmatinib hydrochloride	99.48%	Unkown

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05197	GAB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10503	PIGU Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gab1	NCBI	NCBI:2549

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