2. Gene
  3. Eif4g2 - eukaryotic translation initiation factor 4, gamma 2 Gene

Eif4g2 - eukaryotic translation initiation factor 4, gamma 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 361628 | Gene type: protein coding

About Eif4g2

Summary

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse and rat. [provided by RefSeq, Jul 2008]

Eif4g2 Products(1)

mRNA Protein Name
NM_001017374.2 NP_001017374.2 eukaryotic translation initiation factor 4 gamma 2
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in heart development IEP
IEP: Inferred from expression pattern
10471355 RGD
involved in positive regulation of axon extension IMP
IMP: Inferred from mutant phenotype
23616526 RGD
involved in positive regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
22514323 RGD
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
22514323 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
23616526 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 4 gamma 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04282 EIF4G2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif4g2 NCBI NCBI:1982