Hnrnpa2b1 - heterogeneous nuclear ribonucleoprotein A2/B1 Gene

Also Known as hnRNP; Hnrpa2; Hnrpa2b1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 362361

Summary

Enables DNA Polymerase binding activity and nucleic acid binding activity. Involved in several processes, including chromosome organization; mRNA export from nucleus; and regulation of DNA metabolic process. Located in several cellular components, including chromosome; neuronal ribonucleoprotein granule; and nuclear lumen. Is active in glutamatergic synapse and postsynaptic cytosol. Used to study rheumatoid arthritis. Biomarker of hepatocellular carcinoma; pancreatic carcinoma; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in inclusion body myopathy with Paget disease of bone and frontotemporal dementia and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2. Orthologous to human HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1). [provided by Alliance of Genome Resources, Apr 2022]

Hnrnpa2b1 Products (1)

mRNA Protein Name
NM_001104613.2 NP_001098083.2 heterogeneous nuclear ribonucleoproteins A2/B1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA polymerase binding IPI
IPI: Inferred from physical interaction
23184978 RGD
enables G-rich strand telomeric DNA binding IDA
IDA: Inferred from direct assay
23184978 RGD
enables RNA binding IDA
IDA: Inferred from direct assay
10567417 RGD
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
9578590 RGD
enables mRNA CDS binding IDA
IDA: Inferred from direct assay
16980303 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16518874 RGD
enables regulatory region RNA binding IDA
IDA: Inferred from direct assay
9578590 RGD
enables single-stranded telomeric DNA binding IDA
IDA: Inferred from direct assay
15659580 RGD
Biological Process GO Annotation Evidence References Source
involved in G-quadruplex DNA unwinding IDA
IDA: Inferred from direct assay
23184978 RGD
involved in RNA transport IMP
IMP: Inferred from mutant phenotype
14523087 RGD
involved in lung development IEP
IEP: Inferred from expression pattern
9761751 RGD
involved in mRNA export from nucleus IDA
IDA: Inferred from direct assay
9578590 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
10978504 RGD
involved in oligodendrocyte differentiation IEP
IEP: Inferred from expression pattern
14991837 RGD
involved in positive regulation of telomere maintenance via telomere lengthening IDA
IDA: Inferred from direct assay
23184978 RGD
involved in response to mineralocorticoid IEP
IEP: Inferred from expression pattern
23139218 RGD
involved in telomere capping IDA
IDA: Inferred from direct assay
15659580 RGD
Cellular Component GO Annotation Evidence References Source
located in Cajal body IDA
IDA: Inferred from direct assay
23184978 RGD
located in chromatin IDA
IDA: Inferred from direct assay
12415010 RGD
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
23184978 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
22238095 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
22238095 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12415010 RGD
located in neuronal ribonucleoprotein granule IDA
IDA: Inferred from direct assay
14523087 RGD
located in nuclear matrix IDA
IDA: Inferred from direct assay
23184978 RGD
located in nucleus IDA
IDA: Inferred from direct assay
10567417 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
14991837 RGD
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
25286195 RGD
is active in postsynaptic density EXP
EXP: Inferred from Experiment
22238095 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
22238095 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

heterogeneous nuclear ribonucleoproteins A2/B1

  • heterogeneous nuclear ribonucleoprotein A2

  • heterogeneous nuclear ribonucleoprotein B0a

  • heterogeneous nuclear ribonucleoprotein B0b

  • heterogeneous nuclear ribonucleoprotein B1

  • hnRNP A2 / hnRNP B1

  • hnRNP A2/B1

  • nuclear ribonucleoprotein particle A2 prote

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N13009 MO-2097 / Unkown
HY-RS06262 HNRNPA2B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18110 Hnrnpa2b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24584 Hnrnpa2b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hnrnpa2b1 NCBI NCBI:3181