Hnrnpa2b1 - heterogeneous nuclear ribonucleoprotein A2/B1 Gene

Rattus norvegicus

Also known as hnRNP; Hnrpa2; Hnrpa2b1

Gene ID: 362361 | Gene type: protein coding

About Hnrnpa2b1

Summary

Enables DNA Polymerase binding activity and nucleic acid binding activity. Involved in several processes, including chromosome organization; mRNA export from nucleus; and regulation of DNA metabolic process. Located in several cellular components, including chromosome; neuronal ribonucleoprotein granule; and nuclear lumen. Is active in glutamatergic synapse and postsynaptic cytosol. Used to study rheumatoid arthritis. Biomarker of hepatocellular carcinoma; pancreatic carcinoma; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in inclusion body myopathy with Paget disease of bone and frontotemporal dementia and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2. Orthologous to human HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1). [provided by Alliance of Genome Resources, Apr 2022]

Hnrnpa2b1 Products(1)

mRNA	Protein	Name
NM_001104613.2	NP_001098083.2	heterogeneous nuclear ribonucleoproteins A2/B1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA polymerase binding	IPI IPI: Inferred from physical interaction	23184978	RGD
enables G-rich strand telomeric DNA binding	IDA IDA: Inferred from direct assay	23184978	RGD
enables RNA binding	IDA IDA: Inferred from direct assay	10567417	RGD
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	9578590	RGD
enables mRNA CDS binding	IDA IDA: Inferred from direct assay	16980303	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16518874	RGD
enables regulatory region RNA binding	IDA IDA: Inferred from direct assay	9578590	RGD
enables single-stranded telomeric DNA binding	IDA IDA: Inferred from direct assay	15659580	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G-quadruplex DNA unwinding	IDA IDA: Inferred from direct assay	23184978	RGD
involved in RNA transport	IMP IMP: Inferred from mutant phenotype	14523087	RGD
involved in lung development	IEP IEP: Inferred from expression pattern	9761751	RGD
involved in mRNA export from nucleus	IDA IDA: Inferred from direct assay	9578590	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	10978504	RGD
involved in oligodendrocyte differentiation	IEP IEP: Inferred from expression pattern	14991837	RGD
involved in positive regulation of telomere maintenance via telomere lengthening	IDA IDA: Inferred from direct assay	23184978	RGD
involved in response to mineralocorticoid	IEP IEP: Inferred from expression pattern	23139218	RGD
involved in telomere capping	IDA IDA: Inferred from direct assay	15659580	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Cajal body	IDA IDA: Inferred from direct assay	23184978	RGD
located in chromatin	IDA IDA: Inferred from direct assay	12415010	RGD
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	23184978	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	22238095	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22238095	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12415010	RGD
located in neuronal ribonucleoprotein granule	IDA IDA: Inferred from direct assay	14523087	RGD
located in nuclear matrix	IDA IDA: Inferred from direct assay	23184978	RGD
located in nucleus	IDA IDA: Inferred from direct assay	10567417	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	14991837	RGD
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	25286195	RGD
is active in postsynaptic density	EXP EXP: Inferred from Experiment	22238095	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	22238095	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

heterogeneous nuclear ribonucleoproteins A2/B1

heterogeneous nuclear ribonucleoprotein A2	heterogeneous nuclear ribonucleoprotein B0a
heterogeneous nuclear ribonucleoprotein B0b	heterogeneous nuclear ribonucleoprotein B1
hnRNP A2 / hnRNP B1	hnRNP A2/B1
nuclear ribonucleoprotein particle A2 prote

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N13009	MO-2097		/	Unkown
HY-RS06262	HNRNPA2B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18110	Hnrnpa2b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24584	Hnrnpa2b1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hnrnpa2b1	NCBI	NCBI:3181
Mus musculus	Hnrnpa2b1	NCBI	NCBI:53379

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