Ppfia2 - PTPRF interacting protein alpha 2 Gene

Rattus norvegicus

Gene ID: 362876 | Gene type: protein coding

About Ppfia2

Summary

A structural constituent of presynapse. Involved in regulation of synaptic vesicle exocytosis. Is active in glutamatergic synapse. Orthologous to human PPFIA2 (PTPRF interacting protein alpha 2). [provided by Alliance of Genome Resources, Apr 2022]

Ppfia2 Products(1)

mRNA	Protein	Name
NM_001108745.1	NP_001102215.1	liprin-alpha-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables structural constituent of postsynaptic density	EXP EXP: Inferred from Experiment	30021165	RGD
enables structural constituent of postsynaptic density	IDA IDA: Inferred from direct assay	30021165	RGD
enables structural constituent of postsynaptic density	IMP IMP: Inferred from mutant phenotype	30021165	RGD
enables structural constituent of presynapse	IDA IDA: Inferred from direct assay	23751498	RGD
enables structural constituent of presynapse	IMP IMP: Inferred from mutant phenotype	23751498	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	23751498	RGD
involved in regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	23751498	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	30021165	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23751498	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23751498	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	30021165	RGD
is active in postsynaptic density	IMP IMP: Inferred from mutant phenotype	30021165	RGD
is active in postsynaptic specialization	IDA IDA: Inferred from direct assay	11931740	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	11931740	RGD
is active in synaptic vesicle	IDA IDA: Inferred from direct assay	11931740	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

liprin-alpha-2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10940	PPFIA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppfia2	NCBI	NCBI:8499

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