Runx2 - RUNX family transcription factor 2 Gene

Also Known as Cbfa1; OSF-2; CBF-alpha-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 367218

Summary

Enables DNA-binding transcription factor binding activity; general transcription initiation factor binding activity; and histone deacetylase binding activity. Involved in cellular response to Fibroblast Growth Factor stimulus; osteoblast differentiation; and positive regulation of ossification. Located in nucleus. Human ortholog(s) of this gene implicated in cleidocranial dysplasia and metaphyseal dysplasia-maxillary hypoplasia-brachydacty syndrome. Orthologous to human RUNX2 (RUNX family transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Runx2 Products (2)

mRNA Protein Name
NM_001278483.1 NP_001265412.1 runt-related transcription factor 2 isoform 1
NM_001278484.2 NP_001265413.1 runt-related transcription factor 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
18171674 RGD
enables general transcription initiation factor binding IPI
IPI: Inferred from physical interaction
18171674 RGD
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
20097749 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17251981 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: Inferred from expression pattern
12403780 RGD
involved in cellular response to zinc ion starvation IEP
IEP: Inferred from expression pattern
21893222 RGD
involved in osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
19940863 RGD
involved in positive regulation of ossification IMP
IMP: Inferred from mutant phenotype
11784711 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
20818503 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
20818503 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

runt-related transcription factor 2

  • core-binding factor subunit alpha-1

  • osteoblast-specific transcription factor 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-Y0332B Potassium dihydrogen phosphate, AR,99.5% Activator 99.7% Unkown
HY-P5832 BMP2-derived peptide Activator 98.04% Unkown
HY-107245 Segetalin B Activator 99.9% Unkown
HY-Y0332K Potassium dihydrogen phosphate, for cell culture Activator / Unkown
HY-W014410 Mucic acid Activator 99.36% Unkown
HY-W019901B Anhydrous calcium sulfate (97%) Activator 99.40% Unkown
HY-N2120 Dichotomitin Inducer 99.18% Unkown
HY-P11087 P15 99.46% Unkown
HY-W115785 Zinc borate Activator 0 Unkown
HY-Y0332L Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340 Activator / Unkown
HY-Y0332J Potassium dihydrogen phosphate, United States Pharmacopeia (USP) Reference Standard Activator / Unkown
HY-W014410R Mucic acid (Standard) Activator / Unkown
HY-Y0332G Potassium dihydrogen phosphate, for molecular biology Activator / Unkown
HY-187131 Magnesium malate Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Runx2 NCBI NCBI:860