2. Others TGF-beta/Smad Stem Cell/Wnt Protein Tyrosine Kinase/RTK
  3. RUNX VEGFR Environmental Pollutants
  4. Zinc borate

Zinc borate is a bioactive inorganic substance with properties including osteogenic induction, pro-angiogenesis, antioxidation, antimutagenesis and cytotoxicity. In the field of bone tissue engineering, Zinc borate is often incorporated into chitosan scaffolds. By releasing zinc ions and borate ions, Zinc borate induces the differentiation of human dental pulp stem cells into osteoblasts, upregulates the expression of bone-related genes and promotes calcium deposition. Zinc borate also promotes angiogenesis by upregulating key factors such as vascular endothelial growth factor. Zinc borate exhibits antioxidant capacity to scavenge free radicals, and can specifically reduce mutagenicity under specific conditions. Zinc borate reduces the survival rate of mouse fibroblasts, but it can still be used in studies related to bone tissue engineering.

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Zinc borate

Zinc borate Chemical Structure

CAS No. : 1332-07-6

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Zinc borate Related Antibodies

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Description

Zinc borate is a bioactive inorganic substance with properties including osteogenic induction, pro-angiogenesis, antioxidation, antimutagenesis and cytotoxicity. In the field of bone tissue engineering, Zinc borate is often incorporated into chitosan scaffolds. By releasing zinc ions and borate ions, Zinc borate induces the differentiation of human dental pulp stem cells into osteoblasts, upregulates the expression of bone-related genes and promotes calcium deposition. Zinc borate also promotes angiogenesis by upregulating key factors such as vascular endothelial growth factor. Zinc borate exhibits antioxidant capacity to scavenge free radicals, and can specifically reduce mutagenicity under specific conditions. Zinc borate reduces the survival rate of mouse fibroblasts, but it can still be used in studies related to bone tissue engineering[1][2].

IC50 & Target

RUNX2

 

In Vitro

When zinc borate (1.0% (w/v); 7-21 d) is loaded on chitosan scaffolds, it supports stem cells from human exfoliated deciduous teeth (SHEDs), significantly improving cell viability, with absorbance values at 570 nm of approximately 0.29, 0.41, and 0.57, respectively; it also significantly upregulates ALP activity[1].
Zinc borate (1.0% (w/v); 7-21 d) incorporated into chitosan scaffolds supports SHEDs, significantly upregulating the expression of osteogenesis-related genes (Runx2, OPN, and OCN) and angiogenesis-related genes (VEGF, Ang-1) during osteogenic differentiation[1].
Zinc borate (1 mg/mL; 30 min) exhibits low DPPH free radical scavenging activity in cell-free assays, with an inhibition rate of 13.50% at 1 mg/mL[2].
Zinc borate (0.04-0.2 mg; 72 h) exhibits low antimutagenic activity against 4-NPD-induced mutagenicity in Salmonella typhimurium strain TA98, but shows no antimutagenic activity against sodium azide-induced mutagenicity in strain TA100[2].
Zinc borate (0.3-76.19 μg/mL; 24-72 h) exhibits cytotoxicity against mouse fibroblast L929 cells, with an IC50 value of 40.70 μg/mL at 24 h and 32.93 μg/mL at 72 h[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zinc borate Related Antibodies

Real Time qPCR[1]

Cell Line: stem cells from human exfoliated deciduous teeth (SHEDs)
Concentration: 1.0% (w/v)
Incubation Time: 7, 14, 21 days (cell culture); 45 cycles (RT-PCR)
Result: Showed the highest expression of Runx2 after 14 days of culture.
Showed the highest expression of OPN and OCN after 21 days of culture.
Exhibited high expression of VEGF and Ang-1 across culture time points.
Had all gene expression levels significantly higher than those in pure chitosan scaffolds.

Immunofluorescence[1]

Cell Line: stem cells from human exfoliated deciduous teeth (SHEDs)
Concentration: 1.0% (w/v)
Incubation Time: 7, 21 days (cell culture); 1 h (primary antibody incubation); 1 h (secondary antibody incubation)
Result: Showed notable expression of the early osteoblastic marker BMP-2 after 7 days of culture.
Showed notable expression of the late osteoblastic marker OCN after 21 days of culture.
Molecular Weight

313.76

Formula

Zn3(BO3)2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=BB(OO[Zn])OOO[Zn][Zn]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature, keep dry and cool

In solvent -80°C 1 year
-20°C 6 months
Purity & Documentation
References
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Zinc borate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zinc borate1332-07-6RUNXVEGFREnvironmental PollutantsRunt-related transcription factorsVascular endothelial growth factor receptorEnvironmental ContaminantsSHEDsDPPH free radicalsvascular endothelial growth factor4-nitro-o-phenylenediaminechitosan scaffoldsSalmonella typhimurium TA98 strainmouse fibroblast cellsSalmonella typhimurium TA100 strainhuman dental stem cellsangiopoietin-1Inhibitorinhibitorinhibit

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