ITIH1 - inter-alpha-trypsin inhibitor heavy chain 1 Gene

Also Known as H1P; ITIH; SHAP; IATIH; IGHEP1; ITI-HC1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3697

About ITIH1

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,777,599-52,792,068 (from NCBI)

This gene has 12 transcripts (splice variants), 102 orthologues and 11 paralogues. Restricted expression toward liver (RPKM 383.5).

Summary

This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3. [provided by RefSeq, Nov 2015]

ITIH1 Products (4)

mRNA Protein Name
NM_001166434.3 NP_001159906.1 inter-alpha-trypsin inhibitor heavy chain H1 isoform b
NM_001166435.2 NP_001159907.1 inter-alpha-trypsin inhibitor heavy chain H1 isoform c
NM_001166436.2 NP_001159908.1 inter-alpha-trypsin inhibitor heavy chain H1 isoform c
NM_002215.4 NP_002206.2 inter-alpha-trypsin inhibitor heavy chain H1 isoform a preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables carbohydrate binding EXP
EXP: Inferred from Experiment
7513643 GOA
enables hyaluronic acid binding IDA
IDA: Inferred from direct assay
20463016 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16873769 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITIH1 Protein Structure

VIT

VIT: Vault protein inter-alpha-trypsin domain (50 - 166)

VWA

VWA: von Willebrand factor type A domain (292 - 465)

ITI_HC_C

ITI_HC_C: Inter-alpha-trypsin inhibitor heavy chain C-terminus (705 - 892)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 911 a.a.
Protein Preferred Names Protein Names

inter-alpha-trypsin inhibitor heavy chain H1

  • ITI heavy chain H1

ITIH1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89737 ITI-H1 Antibody (YA9081) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06974 ITIH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ITIH1 VGNC VGNC:67859
Bos taurus ITIH1 VGNC VGNC:30334
Mus musculus ITIH1 MGD MGI:96618
Canis familiaris ITIH1 VGNC VGNC:42145
Rattus norvegicus ITIH1 RGD RGD:1306099
Macaca mulatta ITIH1 VGNC VGNC:73793
Others ITIH1 NCBI