MIGA1 - mitoguardin 1 Gene

Also Known as FAM73A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 374986

About MIGA1

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:77,779,649-77,879,540 (from NCBI)

This gene has 9 transcripts (splice variants), 202 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 8.8), thyroid (RPKM 7.5) and 25 other tissues.

Summary

Enables protein heterodimerization activity and protein homodimerization activity. Involved in mitochondrial fusion. Located in mitochondrion. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

MIGA1 Products (16)

mRNA Protein Name
NM_001270384.2 NP_001257313.1 mitoguardin 1 isoform 2
NM_001363583.1 NP_001350512.1 mitoguardin 1 isoform 3
NM_001363584.1 NP_001350513.1 mitoguardin 1 isoform 3
NM_001363586.1 NP_001350515.1 mitoguardin 1 isoform 3
NM_001394566.1 NP_001381495.1 mitoguardin 1 isoform 4
NM_001394567.1 NP_001381496.1 mitoguardin 1 isoform 5
NM_001394568.1 NP_001381497.1 mitoguardin 1 isoform 5
NM_001394569.1 NP_001381498.1 mitoguardin 1 isoform 5
NM_001394570.1 NP_001381499.1 mitoguardin 1 isoform 5
NM_001394571.1 NP_001381500.1 mitoguardin 1 isoform 3
NM_001394572.1 NP_001381501.1 mitoguardin 1 isoform 6
NM_001394573.1 NP_001381502.1 mitoguardin 1 isoform 7
NM_001394574.1 NP_001381503.1 mitoguardin 1 isoform 8
NM_001394575.1 NP_001381504.1 mitoguardin 1 isoform 9
NM_001394576.1 NP_001381505.1 mitoguardin 1 isoform 9
NM_198549.4 NP_940951.1 mitoguardin 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26711011 GOA
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
26711011 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
26711011 GOA
Biological Process GO Annotation Evidence References Source
involved in mitochondrial fusion IDA
IDA: Inferred from direct assay
26711011 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
26711011 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MIGA1 Protein Structure

Miga

Miga: Mitoguardin (59 - 603)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 632 a.a.
Protein Preferred Names Protein Names

mitoguardin 1

  • family with sequence similarity 73, member A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08446 MIGA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MIGA1 VGNC VGNC:43232
Bos taurus MIGA1 VGNC VGNC:31473
Macaca mulatta MIGA1 VGNC VGNC:74819
Mus musculus MIGA1 MGD MGI:1924567
Felis catus MIGA1 VGNC VGNC:63504
Rattus norvegicus MIGA1 RGD RGD:1559958
Others MIGA1 NCBI