STIMATE - STIM activating enhancer Gene

Also Known as TMEM110

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 375346

About STIMATE

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,836,733-52,897,548 (from NCBI)

This gene has 6 transcripts (splice variants), 194 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 12.1), lung (RPKM 12.0) and 25 other tissues.

Summary

Enables Calcium Channel regulator activity. Involved in activation of store-operated Calcium Channel activity; calcium-mediated signaling using intracellular calcium source; and positive regulation of calcineurin-NFAT signaling cascade. Located in cortical endoplasmic reticulum; endoplasmic reticulum membrane; and endoplasmic reticulum-plasma membrane contact site. [provided by Alliance of Genome Resources, Apr 2022]

STIMATE Products (1)

mRNA	Protein	Name
NM_198563.5	NP_940965.1	store-operated calcium entry regulator STIMATE

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium channel regulator activity	IDA IDA: Inferred from direct assay	26322679	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26322679	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of store-operated calcium channel activity	IDA IDA: Inferred from direct assay	26322679	GOA
involved in store-operated calcium entry	IDA IDA: Inferred from direct assay	26644574	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cortical endoplasmic reticulum	IDA IDA: Inferred from direct assay	26322679	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	26322679	GOA
located in endoplasmic reticulum-plasma membrane contact site	IDA IDA: Inferred from direct assay	26644574	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STIMATE Protein Structure

STIMATE

0
100
200
294 a.a.

Protein Preferred Names	Protein Names
store-operated calcium entry regulator STIMATE	STIM-activating enhancer encoded by TMEM110

Related Diseases

Diseases	Alias
Stormorken Syndrome	Thrombocytopathy, Asplenia, And Miosis Stormorken-Sjaastad-Langslet Syndrome STRMK York Platelet Syndrome Yps Thrombocytopathy, Asplenia And Miosis Thrombocytopathy Asplenia Miosis Thrombocytopathy-Asplenia-Miosis Syndrome Miosis Disorder
Capgras Syndrome	Capgras Delusion Theory
Cenani-Lenz Syndactyly Syndrome	Syndactyly Type 7 Cenani Syndactylism Cenani-Lenz Syndactyly CLSS Syndactyly Cenani Lenz Type Cenani-Lenz Syndrome Syndactyly, Type Vii Cenani-Lenz Type Syndactyly Cenani Syndactyly Syndactyly Type Vii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13915	STIMATE Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	STIMATE	MGD	MGI:1921500