MAST4 - microtubule associated serine/threonine kinase family member 4 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 375449

About MAST4

Cytogenetic location: 5q12.3 Genomic coordinates (GRCh38): 5:66,596,393-67,169,593 (from NCBI)

This gene has 21 transcripts (splice variants), 252 orthologues and 13 paralogues. Ubiquitous expression in esophagus (RPKM 3.2), fat (RPKM 2.7) and 23 other tissues.

Summary

This gene encodes a member of the microtubule-associated serine/threonine protein kinases. The proteins in this family contain a domain that gives the kinase the ability to determine its own scaffold to control the effects of their kinase activities. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

MAST4 Products (12)

mRNA Protein Name
NM_001164664.2 NP_001158136.1 microtubule-associated serine/threonine-protein kinase 4 isoform 3
NM_001290226.2 NP_001277155.1 microtubule-associated serine/threonine-protein kinase 4 isoform 4
NM_001290227.2 NP_001277156.1 microtubule-associated serine/threonine-protein kinase 4 isoform 5
NM_001290228.2 NP_001277157.1 microtubule-associated serine/threonine-protein kinase 4 isoform 6
NM_001297651.2 NP_001284580.1 microtubule-associated serine/threonine-protein kinase 4 isoform 7
NM_001393524.1 NP_001380453.1 microtubule-associated serine/threonine-protein kinase 4 isoform 8
NM_001393525.1 NP_001380454.1 microtubule-associated serine/threonine-protein kinase 4 isoform 9
NM_001393526.1 NP_001380455.1 microtubule-associated serine/threonine-protein kinase 4 isoform 10
NM_001393527.1 NP_001380456.1 microtubule-associated serine/threonine-protein kinase 4 isoform 5
NM_001393528.1 NP_001380457.1 microtubule-associated serine/threonine-protein kinase 4 isoform 12
NM_015183.3 NP_055998.1 microtubule-associated serine/threonine-protein kinase 4 isoform 1
NM_198828.3 NP_942123.1 microtubule-associated serine/threonine-protein kinase 4 isoform 2

MAST4 Protein Structure

DUF1908

DUF1908: Domain of unknown function (DUF1908) (258 - 532)

Pkinase

Pkinase: Protein kinase domain (571 - 843)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (1169 - 1224)

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  • 2623 a.a.
Protein Preferred Names Protein Names

microtubule-associated serine/threonine-protein kinase 4

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 27

  • Spinocerebellar Ataxia Type 27

  • SCA27

  • Cerebellar Ataxia Autosomal Dominant Fgf14-Related

  • Vestibulocerebellar Disorder With Predominant Ocular Signs

  • Cerebellar Ataxia, Autosomal Dominant, Fgf14-Related

  • Nystagmus 4, Congenital, Autosomal Dominant, Formerly

  • Nys4, Formerly

  • Ataxia, Spinocerebellar, Type 27
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08164 MAST4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22626 Mast4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29141 Mast4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MAST4 VGNC VGNC:74534
Bos taurus MAST4 VGNC VGNC:58387
Canis familiaris MAST4 VGNC VGNC:43035
Mus musculus MAST4 MGD MGI:1918885
Rattus norvegicus MAST4 RGD RGD:1310139
Felis catus MAST4 VGNC VGNC:102250
Others MAST4 NCBI