RAB15 - RAB15, member RAS oncogene family Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 376267

About RAB15

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:64,945,816-64,972,336 (from NCBI)

This gene has 10 transcripts (splice variants), 264 orthologues and 68 paralogues. Broad expression in brain (RPKM 21.8), urinary bladder (RPKM 12.3) and 21 other tissues.

Summary

Predicted to enable GTP binding activity and GTPase activity. Involved in positive regulation of regulated secretory pathway. Located in cilium; endosome membrane; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RAB15 Products (3)

mRNA Protein Name
NM_001308154.2 NP_001295083.1 ras-related protein Rab-15 isoform 2
NM_001330182.2 NP_001317111.1 ras-related protein Rab-15 isoform 3
NM_198686.3 NP_941959.1 ras-related protein Rab-15 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16195351 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of regulated secretory pathway IGI
IGI: Inferred from genetic interaction
22899725 GOA
involved in positive regulation of regulated secretory pathway IMP
IMP: Inferred from mutant phenotype
22899725 GOA
Cellular Component GO Annotation Evidence References Source
located in cilium IDA
IDA: Inferred from direct assay
17646400 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
16195351 GOA
located in endosome membrane IDA
IDA: Inferred from direct assay
16195351 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16195351 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB15 Protein Structure

Ras

Ras: Ras family (10 - 170)

  • 0
  • 100
  • 200
  • 212 a.a.
Protein Preferred Names Protein Names

ras-related protein Rab-15

  • RAB15, member RAS onocogene family

Related Diseases

Diseases Alias
Immunodeficiency 54

  • Natural Killer Cell Deficiency, Familial Isolated

  • Primary Immunodeficiency With Natural-Killer Cell Deficiency And Adrenal Insufficiency

  • IMD54

  • Nkcd

  • Natural Killer Cell And Glucocorticoid Deficiency With Dna Repair Defect

  • Nkgcd

  • Familial Isolated Natural Killer Cell Deficiency

  • Primary Immunodeficiency Due To Mcm4 Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11524 RAB15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RAB15 RGD RGD:735172
Mus musculus RAB15 MGD MGI:1916865
Bos taurus RAB15 VGNC VGNC:33623
Macaca mulatta RAB15 VGNC VGNC:81519
Canis familiaris RAB15 VGNC VGNC:45255
Felis catus RAB15 VGNC VGNC:104611
Others RAB15 NCBI