KCNK2 - potassium two pore domain channel subfamily K member 2 Gene

Also Known as TREK; TPKC1; TREK1; K2p2.1; TREK-1; hTREK-1c; hTREK-1e

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3776

About KCNK2

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:215,005,542-215,237,090 (from NCBI)

This gene has 9 transcripts (splice variants), 282 orthologues and 14 paralogues. Biased expression in adrenal (RPKM 18.5), thyroid (RPKM 2.6) and 1 other tissue.

Summary

This gene encodes one of the members of the two-pore-domain background Potassium Channel protein family. This type of Potassium Channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

KCNK2 Products (3)

mRNA Protein Name
NM_001017424.3 NP_001017424.1 potassium channel subfamily K member 2 isoform a
NM_001017425.3 NP_001017425.2 potassium channel subfamily K member 2 isoform c
NM_014217.4 NP_055032.1 potassium channel subfamily K member 2 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables mechanosensitive potassium channel activity IDA
IDA: Inferred from direct assay
38605031 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNK2 Protein Structure

Ion_trans_2

Ion_trans_2: Ion channel (128 - 196)

Ion_trans_2

Ion_trans_2: Ion channel (234 - 312)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 426 a.a.
Protein Preferred Names Protein Names

potassium channel subfamily K member 2

  • K2P2.1 potassium channel

Related Diseases

Diseases Alias
Dentin Sensitivity

  • Sensitive Dentin
Birk-Barel Syndrome

  • Birk-Barel Mental Retardation Dysmorphism Syndrome

  • BIBARS

  • Mental Retardation With Hypotonia And Facial Dysmorphism

  • Intellectual Disability-Hypotonia-Facial Dysmorphism Syndrome

  • Kcnk9 Imprinting Syndrome
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2x

  • Lgmd2x

  • Muscular Dystrophy, Limb-Girdle, Type 2x
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema

  • Dehydrated Hereditary Stomatocytosis

  • Hereditary Xerocytosis

  • Xerocytosis, Hereditary

  • Pshk1

  • Pseudohyperkalemia Edinburgh

  • Dehydrated Hereditary Stomatocytosis With Or Without Pseudohyperkalemia And/Or Perinatal Edema

  • DHS1

  • Dhs

  • Hereditary Desiccytosis

  • Dehydrated Hereditary Stomatocytosis 1

  • Desiccytosis, Hereditary

  • Pseudohyperkalemia, Familial, 1, Due To Red Cell Leak

  • Pseudohyperkalemia Familial 1, Due To Red Cell Leak

  • Desiccytosis Hereditary

  • Xerocytosis Hereditary

  • Familial Pseudohyperkalemia 1 Due To Red Cell Leak

  • Stomatocytosis, Dehydrated, Hereditary, With/Without Pseudohyperkalemia And/Or Perinatal Edema

  • Xerocytosis
Migraine With Or Without Aura 1

  • Migraine

  • Migraine With Or Without Aura, Susceptibility To, 1

  • Migraine Disorder

  • Migraine Variant

  • Migraines

  • Migraine Disorders

  • Mgr1

  • Mgau

  • Ma

  • Migraine With Or Without Aura

  • Classic Migraine

  • Common Migraine

  • Disorder, Migraine

  • Headache Migraine

  • Headache Migrainous

  • Migraine Headache

  • Migraine Syndrome

  • Headache Including Migraine

  • Migraine, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-B1500 2,2,2-Trichloroethanol Agonist 99.53% Unkown
HY-RS07158 KCNK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18069 Kcnk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24544 Kcnk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus KCNK2 RGD RGD:621448
Bos taurus KCNK2 VGNC VGNC:30472
Macaca mulatta KCNK2 VGNC VGNC:99988
Felis catus KCNK2 VGNC VGNC:67920
Mus musculus KCNK2 MGD MGI:109366
Canis familiaris KCNK2 VGNC VGNC:42274