Tmem237 - transmembrane protein 237 Gene

Also Known as Gm972; Als2cr4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 381259

Summary

Involved in cilium assembly and regulation of Wnt signaling pathway. Located in cone photoreceptor outer segment; photoreceptor connecting cilium; and rod photoreceptor outer segment. Is expressed in alimentary system; gallbladder; lower urinary tract; and reproductive system. Human ortholog(s) of this gene implicated in Joubert syndrome and Joubert syndrome 14. Orthologous to human TMEM237 (transmembrane protein 237). [provided by Alliance of Genome Resources, Apr 2022]

Tmem237 Products (3)

mRNA Protein Name
NM_001033449.2 NP_001028621.1 transmembrane protein 237 isoform 1
NM_001037812.3 NP_001032901.1 transmembrane protein 237 isoform 2
NM_001361413.1 NP_001348342.1 transmembrane protein 237 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20375344 MGI
Biological Process GO Annotation Evidence References Source
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
22152675 MGI
involved in regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
22152675 MGI
Cellular Component GO Annotation Evidence References Source
located in ciliary transition zone IDA
IDA: Inferred from direct assay
22152675 MGI
located in cone photoreceptor outer segment IDA
IDA: Inferred from direct assay
20375344 MGI
located in photoreceptor connecting cilium IDA
IDA: Inferred from direct assay
20375344 MGI
located in rod photoreceptor outer segment IDA
IDA: Inferred from direct assay
20375344 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transmembrane protein 237

  • amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4

  • amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14706 TMEM237 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tmem237 NCBI NCBI:65062