Xkr8 - X-linked Kx blood group related 8 Gene

Mus musculus

Also known as XRG8; mXkr8; Gm1031; 4931440N07Rik

Gene ID: 381560 | Gene type: protein coding

About Xkr8

Summary

Enables phospholipid scramblase activity. Involved in engulfment of apoptotic cell; neutrophil clearance; and phosphatidylserine exposure on apoptotic cell surface. Acts upstream of or within establishment of localization in cell; positive regulation of myoblast differentiation; and tolerance induction to self antigen. Is active in plasma membrane. Orthologous to human XKR8 (XK related 8). [provided by Alliance of Genome Resources, Apr 2022]

Xkr8 Products(1)

mRNA	Protein	Name
NM_201368.1	NP_958756.1	XK-related protein 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phospholipid scramblase activity	IDA IDA: Inferred from direct assay	25231987	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in engulfment of apoptotic cell	IMP IMP: Inferred from mutant phenotype	29440417	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	29440417	MGI
involved in neutrophil clearance	IMP IMP: Inferred from mutant phenotype	29440417	MGI
involved in phosphatidylserine exposure on apoptotic cell surface	IDA IDA: Inferred from direct assay	25231987	MGI
acts upstream of or within phosphatidylserine exposure on apoptotic cell surface	IMP IMP: Inferred from mutant phenotype	29440417	MGI
involved in phosphatidylserine exposure on apoptotic cell surface	IMP IMP: Inferred from mutant phenotype	23845944	MGI
involved in positive regulation of myoblast differentiation	IMP IMP: Inferred from mutant phenotype	28881496	MGI
acts upstream of or within tolerance induction to self antigen	IMP IMP: Inferred from mutant phenotype	29440417	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	25231987	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

XK-related protein 8

X Kell blood group precursor related family member 8 homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15881	XKR8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Xkr8	NCBI	NCBI:55113

Name
Email *

	Sorry, but the email address you supplied was invalid.