Xkr8 - X-linked Kx blood group related 8 Gene

Also Known as XRG8; mXkr8; Gm1031; 4931440N07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 381560

Summary

Enables phospholipid scramblase activity. Involved in engulfment of apoptotic cell; neutrophil clearance; and phosphatidylserine exposure on apoptotic cell surface. Acts upstream of or within establishment of localization in cell; positive regulation of myoblast differentiation; and tolerance induction to self antigen. Is active in plasma membrane. Orthologous to human XKR8 (XK related 8). [provided by Alliance of Genome Resources, Apr 2022]

Xkr8 Products (1)

mRNA Protein Name
NM_201368.1 NP_958756.1 XK-related protein 8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phospholipid scramblase activity IDA
IDA: Inferred from direct assay
25231987 MGI
Biological Process GO Annotation Evidence References Source
involved in engulfment of apoptotic cell IMP
IMP: Inferred from mutant phenotype
29440417 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
29440417 MGI
involved in neutrophil clearance IMP
IMP: Inferred from mutant phenotype
29440417 MGI
involved in phosphatidylserine exposure on apoptotic cell surface IDA
IDA: Inferred from direct assay
25231987 MGI
acts upstream of or within phosphatidylserine exposure on apoptotic cell surface IMP
IMP: Inferred from mutant phenotype
29440417 MGI
involved in phosphatidylserine exposure on apoptotic cell surface IMP
IMP: Inferred from mutant phenotype
23845944 MGI
involved in positive regulation of myoblast differentiation IMP
IMP: Inferred from mutant phenotype
28881496 MGI
acts upstream of or within tolerance induction to self antigen IMP
IMP: Inferred from mutant phenotype
29440417 MGI
Cellular Component GO Annotation Evidence References Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
25231987 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

XK-related protein 8

  • X Kell blood group precursor related family member 8 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15881 XKR8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Xkr8 NCBI NCBI:55113